对于假性黏液瘤腹膜病（PMP）的治疗，应考虑在细胞减灭术和腹腔热灌注化疗（HIPEC）前、后使用抗生素。
Pre- and post-operative antibiotics in conjunction with cytoreductive surgery and heated intraperitoneal chemotherapy (HIPEC) should be considered for pseudomyxoma peritonei (PMP) treatment.
机构信息
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.
Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, 20742, USA.
出版信息
Eur J Surg Oncol. 2019 Sep;45(9):1723-1726. doi: 10.1016/j.ejso.2019.01.223. Epub 2019 Jan 30.
Pseudomyxoma peritonei (PMP) is a subtype of peritoneal carcinomatosis that is traditionally treated by cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC). A growing body of evidence suggests that microbes are associated with various tumor types and have been found in organs and cavities that were once considered sterile. Prior and ongoing research from our consortium of PMP researchers strongly suggests that bacteria are associated with PMP tumors. While the significance of this association is unclear, in our opinion, further research is warranted to understand whether these bacteria contribute to the development, maintenance and/or progression of PMP. Elucidation of a possible causal role for bacteria in PMP could suggest a benefit for supplementation of antibiotics to current treatment protocols.
腹膜假黏液瘤（PMP）是腹膜癌病的一种亚型，传统上采用细胞减灭术（CRS）联合腹腔热灌注化疗（HIPEC）治疗。越来越多的证据表明，微生物与各种肿瘤类型有关，并且已经在曾经被认为无菌的器官和腔隙中发现了微生物。我们的腹膜假黏液瘤研究人员联盟的前期和正在进行的研究强烈表明，细菌与 PMP 肿瘤有关。虽然这种关联的意义尚不清楚，但我们认为，有必要进一步研究以了解这些细菌是否有助于 PMP 的发生、维持和/或进展。阐明细菌在 PMP 中可能的因果作用，可以提示在现有治疗方案中补充抗生素可能有益。
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