Bilardo C M, Nicolaides K H
Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, London, UK.
Fetal Ther. 1988;3(1-2):24-30. doi: 10.1159/000263330.
Fetal blood sampling by cordocentesis in a group of 239 severely small-for-gestational age fetuses revealed a high incidence of chromosomal anomalies (17%). Furthermore, some of the fetuses were hypoxemic and demonstrated abnormalities in carbohydrate, lipid and protein metabolism. There were significant correlations between the degree of fetal hypoxemia and abnormalities in Doppler measurements of impedance to flow in the maternal uterine arteries and in the fetal umbilical artery, and of mean blood velocity measured in the fetal descending thoracic aorta and in the common carotid artery. Maternal hyperoxygenation in some cases improved fetal oxygenation and corrected some of the abnormalities in the Doppler measurements of fetal circulation.
对239例严重小于胎龄儿进行脐静脉穿刺采集胎儿血样，结果显示染色体异常的发生率很高（17%）。此外，部分胎儿存在低氧血症，并表现出碳水化合物、脂质和蛋白质代谢异常。胎儿低氧血症的程度与母体子宫动脉和胎儿脐动脉血流阻抗的多普勒测量异常，以及胎儿降主动脉和颈总动脉平均血流速度测量异常之间存在显著相关性。在某些情况下，母体高氧治疗可改善胎儿氧合，并纠正胎儿循环多普勒测量中的一些异常情况。
