外排泵上调：从耐药到高水平抗生素耐药？
Efflux-Pump Upregulation: From Tolerance to High-level Antibiotic Resistance?
机构信息
Department of Biology, Functional Genomics, University of Copenhagen, Copenhagen, Denmark; Center for Peptide-Based Antibiotics, University of Copenhagen, Copenhagen, Denmark.
出版信息
Trends Microbiol. 2019 Apr;27(4):291-293. doi: 10.1016/j.tim.2019.01.005. Epub 2019 Feb 12.
PMID:30770171
Abstract
A recent study shows that high expression of the efflux-pump AcrAB-TolC, which increases antibiotic tolerance, reduces DNA mismatch repair in Escherichia coli to promote spontaneous mutations. Because mutations in target genes can lead to high-level resistance, this highlights how transiently tolerant cells can develop resistance in response to antibiotic treatment.
摘要
最近的一项研究表明，外排泵 AcrAB-TolC 的高表达会增加抗生素耐受性，从而降低大肠杆菌中的 DNA 错配修复，促进自发突变。由于靶基因的突变会导致高水平的耐药性，这突出表明短暂耐受的细胞如何对抗生素治疗产生耐药性。
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