Washington University School of Medicine, St. Louis, Missouri.
Cancer Res. 2019 Feb 15;79(4):704-705. doi: 10.1158/0008-5472.CAN-18-4072.
Mechanistic studies of high-dose irradiation are important to improve our understanding on how the efficacy of stereotactically delivered high-dose irradiation can be enhanced by therapeutics such as ataxia-telangiesctasia-mutated (ATM) inhibitors. In this issue of , Torok and colleagues found that a single 15 Gy radiation dose eliminated lung tumor growth in mice when ATM was deleted in cancer cells versus when deleted in endothelial cells. These data support the establishment of clinical trials testing ATM inhibitors in combination with highly conformal radiotherapy or high-dose rate brachytherapy..
研究大剂量照射的作用机制对于加深理解如何通过诸如共济失调毛细血管扩张突变（ATM）抑制剂等治疗方法增强立体定向给予大剂量照射的疗效非常重要。在本期杂志中，Torok 及其同事发现，与在血管内皮细胞中敲除 ATM 相比，在癌细胞中敲除 ATM 时，单次 15 Gy 的辐射剂量可消除小鼠肺部肿瘤的生长。这些数据支持建立临床试验，以测试 ATM 抑制剂与高适形放疗或高剂量率近距离放疗相结合的效果。
