Ljunggren B, Brandt L, Säveland H, Sonesson B, Romner B, Zygmunt S, Andersson K E, Mellergård P, Ryman T
Department of Neurosurgery, University Hospital, Lund, Sweden.
Br J Neurosurg. 1987;1(1):9-32. doi: 10.3109/02688698709034338.
The discouraging history associated with management of aneurysmal subarachnoid haemorrhage (SAH) is reviewed along with improvements in outlook attributable to progress made within the past decade. Among the new developments is the introduction of microsurgical techniques that allow elective surgery in the acute stage thereby preventing repeat haemorrhages. Early operation also offers the possibility of a more aggressive pharmacological anti-ischaemic treatment. Notwithstanding the improved results of acute elective surgery and the fact that delayed ischaemic deterioration (symptomatic cerebral vasospasm) now may be almost eliminated, the overall outcome remains gloomy. Despite recent advances not more than one out of three individuals, who are struck by the rupture of an intracranial aneurysm, may be expected to make a good neurological and functional recovery. Hope for further improvements may depend on the development of techniques that can identify intracranial aneurysms before they rupture and increased knowledge of the aetiology of such arterial wall lesions.
回顾了与动脉瘤性蛛网膜下腔出血(SAH)治疗相关的令人沮丧的历史,以及过去十年取得的进展所带来的预后改善。新进展包括引入了显微外科技术,该技术允许在急性期进行择期手术,从而预防再次出血。早期手术还提供了更积极的药理学抗缺血治疗的可能性。尽管急性择期手术的结果有所改善,且延迟性缺血性恶化(症状性脑血管痉挛)现在几乎可以消除,但总体预后仍然不容乐观。尽管最近取得了进展,但颅内动脉瘤破裂的患者中,预计每三人中不超过一人能实现良好的神经功能恢复。进一步改善的希望可能取决于能够在颅内动脉瘤破裂前识别它们的技术的发展,以及对这种动脉壁病变病因的更多了解。