先天性膈疝生存的早期产后预测模型比较。
Comparison of early postnatal prediction models for survival in congenital diaphragmatic hernia.
机构信息
Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Division of Pediatric Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.
出版信息
J Perinatol. 2019 May;39(5):654-660. doi: 10.1038/s41372-019-0335-8. Epub 2019 Feb 15.
OBJECTIVE
To compare the PF-PCO equation-partial pressure of arterial oxygen (PaO)/fraction of inspired oxygen (FiO) minus partial pressure of carbon dioxide (PCO)-to three other tools for postnatal prediction of survival in infants with congenital diaphragmatic hernia (CDH).
STUDY DESIGN
A retrospective analysis of 203 infants with CDH from 1 January 2003 to 30 June 2018. Area under the curve (AUC) analysis was performed for survival and secondary outcomes of survival without extracorporeal membrane oxygenation support (ECMO) and death despite ECMO. Predictive scores were calculated to determine cutoff for PF-PCO score.
RESULTS
The PF-PCO tool had the highest AUC (0.84 for survival, 0.92 for survival without ECMO, and 0.83 for death despite ECMO). PF-PCO best predicted survival when >-60 and survival without ECMO when >+80. There was no optimal cutoff score for death despite ECMO.
CONCLUSION
The PF-PCO tool best predicted postnatal survival in infants with CDH.
目的
比较 PF-PCO 方程（动脉血氧分压 [PaO]/吸入氧分数 [FiO]-二氧化碳分压 [PCO]）与其他三种工具，以预测先天性膈疝（CDH）婴儿出生后的存活率。
研究设计
对 203 例 2003 年 1 月 1 日至 2018 年 6 月 30 日期间患有 CDH 的婴儿进行回顾性分析。对存活率及无体外膜肺氧合（ECMO）支持存活率和 ECMO 支持后死亡率等次要结局进行曲线下面积（AUC）分析。计算预测评分，以确定 PF-PCO 评分的截断值。
结果
PF-PCO 工具的 AUC 值最高（存活率为 0.84，无 ECMO 存活率为 0.92，ECMO 支持后死亡率为 0.83）。当 >-60 时，PF-PCO 最佳预测存活率；当 >+80 时，最佳预测无 ECMO 存活率。ECMO 支持后死亡率没有最佳截断值。
结论
PF-PCO 工具最能预测 CDH 婴儿出生后的存活率。
Zotero 插件