Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Neurocrit Care. 2019 Jun;30(3):542-545. doi: 10.1007/s12028-019-00685-9.
Gastrointestinal complications, including hemorrhage, can occur with intracranial lesions and after craniotomy. As early as the 19th century, surgeons were aware that brain tumors could cause gastric ulcers and acute perforations. Investigators used animal experiments both to reproduce these clinical observations and to seek ways to block the effects. Gastrointestinal lesions were seen as a result of the stress of acute brain injury or as a direct consequence of brain surgery. The thinking at the time was markedly influenced by the presumed stress and psychic factors proposed by Cannon. This historical vignette summarizes the major experimental works linking the brain with the stomach.
胃肠道并发症，包括出血，可发生于颅内病变和开颅术后。早在 19 世纪，外科医生就已经意识到脑肿瘤可导致胃溃疡和急性穿孔。研究人员通过动物实验，不仅重现了这些临床观察结果，还寻求了阻断这些影响的方法。胃肠道病变被认为是急性脑损伤的应激反应的结果，或者是脑外科手术的直接后果。当时的想法受到了坎农提出的应激和心理因素的明显影响。这个历史小插曲总结了将大脑与胃联系起来的主要实验工作。
