Yu T, Yu S L, Deng X F, Wang P J, Luo R T, Cai H S L, Wang B, Zhang D, Wang S, Zhao J Z, Zhang Y
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Department of Neurosurgery, Beijing Children's Hospital, Beijing 100045, China.
Zhonghua Yi Xue Za Zhi. 2019 Jan 29;99(5):329-332. doi: 10.3760/cma.j.issn.0376-2491.2019.05.002.
To investigate the functional lateralization of major Chinese language cortex in patients with cerebral arteriovenous malformation (AVM) in dominant hemispheric via functional magnetic resonance imaging (fMRI). Nine right-handed normal volunteers and fourteen patients with cerebral AVM in dominant hemisphere diagnosed in Beijing Tiantan Hospital between December 2017 and June 2018 were included. Three language tasks (semantic judgment, word reading, and listening comprehension) were applied to activate language areas. Lateralization index (LI) was used to show the dominant hemisphere. In the control group, right-sided lateralization of BOLD signal activations was observed in 0/27 (0%) of the language tasks. While in the AVM patients, right-sided lateralization of BOLD signal activations was observed in 8/42 (19%) language tasks. The difference was statistically significant (χ(2)=5.73, 0.019). The dominant hemisphere of different language tasks may be different in patients with cerebral lesions. Compared with normal controls, patients with cerebral AVM in dominant hemispheric are more likely to have right-sided lateralization of language cortex.
通过功能磁共振成像（fMRI）研究优势半球患有脑动静脉畸形（AVM）的患者主要汉语皮质的功能偏侧化。纳入9名右利手正常志愿者以及2017年12月至2018年6月期间在北京天坛医院确诊的14例优势半球患有脑AVM的患者。应用三项语言任务（语义判断、单词阅读和听力理解）来激活语言区域。使用偏侧化指数（LI）来显示优势半球。在对照组中，0/27（0%）的语言任务观察到BOLD信号激活的右侧偏侧化。而在AVM患者中，8/42（19%）的语言任务观察到BOLD信号激活的右侧偏侧化。差异具有统计学意义（χ(2)=5.73，P=0.019）。脑损伤患者不同语言任务的优势半球可能不同。与正常对照组相比，优势半球患有脑AVM的患者更有可能出现语言皮质的右侧偏侧化。
