a Assisted Reproduction Unit, Third Department of Obstetrics and Gynecology , "Attikon Hospital", Medical School, National and Kapodistrian University of Athens , Athens , Greece.
b Second Department of Pathology , "Attikon Hospital", Medical School, National and Kapodistrian University of Athens , Athens , Greece.
Gynecol Endocrinol. 2019 May;35(5):448-452. doi: 10.1080/09513590.2018.1538344. Epub 2019 Feb 18.
Medically assisted reproduction (MAR) technologies have advanced rapidly, but in contrast to the specificity of modern approaches, they provide limited effectiveness in the management of the infertile couple. The purpose of this study was to assess the possible relationship between age at menarche and MAR outcomes of clinical pregnancy, live birth and the adverse incident of miscarriage, and to determine the offspring sex ratio according to age at menarche. In a cohort of 254 infertile couples who underwent 426 IVF/ICSI cycles, statistical analysis was performed by applying Student's t-test, chi-square test, and logistic regression models, adequately in the respective parameters and outcomes. The results indicated a strong association of age at menarche with the outcomes of clinical pregnancy (p = .0007) and live birth (p < .0001), especially by applying a threshold of 12 years in the first occurrence of menstruation (p = .0019 for clinical pregnancy, p < .0001 for live birth), also demonstrating a negative effect for earlier menarche that acts in parallel with the increasing age of the woman. Calculation of sex ratio demonstrated a tendency towards female offspring close to the age at menarche of 12 years. Age at menarche could serve as a surrogate parameter for reproductive potential towards personalized management of infertility.
医学辅助生殖（MAR）技术发展迅速，但与现代方法的特异性相比，它们在处理不孕夫妇方面的效果有限。本研究旨在评估初潮年龄与 MAR 临床妊娠、活产和流产不良事件结局之间的可能关系，并根据初潮年龄确定后代的性别比例。在 254 对接受 426 个 IVF/ICSI 周期的不孕夫妇的队列中，通过应用学生 t 检验、卡方检验和逻辑回归模型对适当的参数和结局进行了统计分析。结果表明，初潮年龄与临床妊娠（p = .0007）和活产（p < .0001）的结局密切相关，尤其是初潮发生在 12 岁时（p = .0019 与临床妊娠，p < .0001 与活产），也表明初潮较早对女性有负面影响，且与女性年龄增长呈平行关系。性别比例的计算显示，接近 12 岁初潮年龄的女婴比例有增加的趋势。初潮年龄可以作为生育潜能的替代参数，用于个性化管理不孕。
