Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan Province, PR China.
Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan Province, PR China.
Clin Genitourin Cancer. 2019 Jun;17(3):e433-e439. doi: 10.1016/j.clgc.2019.01.003. Epub 2019 Jan 10.
The study was carried out to examine the expression of ataxia telangiectasia mutant (ATM) of clear cell renal cell carcinoma (ccRCC), and to explore the relationship between the expression of ATM and the clinicopathologic parameters and prognosis of ccRCC.
Clinicopathologic data of the patients with ccRCC were collected from January 2011 to August 2015 in Xiangya Hospital, Central South University. The immunohistochemical method was used to detect the expression of ATM in ccRCC and adjacent tissues. The Kaplan-Meier survival method and log-rank test were used to analyze the relationship between ATM expression and the survival time of the patients with ccRCC. Univariate and multivariate Cox regression analysis was used to evaluate the risk factors for the prognosis of ccRCC.
A total of 110 patients were selected in this study, including 73 men and 37 women. The expression of ATM in ccRCC is significantly lower than that in adjacent tissues. Further analysis found that the expression of ATM in the ccRCC tissues above grade II was lower than that of grade II or below. Kaplan-Meier survival analysis showed that the total survival time of the ATM low expression group was significantly shorter than that of the ATM high expression group. The multivariate Cox regression analysis showed that expression of ATM and clinical stage were independent factors affecting the prognosis of ccRCC.
ATM expression level could serve as an independent risk factor for the prognosis of ccRCC and could be considered as a potential therapeutic target of ccRCC.
本研究旨在检测常染色体显性遗传小脑共济失调毛细血管扩张症突变（ATM）在透明细胞肾细胞癌（ccRCC）中的表达情况，并探讨其与 ccRCC 临床病理参数及预后的关系。
收集 2011 年 1 月至 2015 年 8 月在中南大学湘雅医院接受治疗的 ccRCC 患者的临床病理资料。采用免疫组织化学法检测 ccRCC 及相邻组织中 ATM 的表达情况。采用 Kaplan-Meier 生存法和 Log-rank 检验分析 ATM 表达与 ccRCC 患者生存时间的关系。采用单因素和多因素 Cox 回归分析评估 ccRCC 预后的危险因素。
本研究共纳入 110 例患者，其中男 73 例，女 37 例。ccRCC 组织中 ATM 的表达明显低于相邻组织。进一步分析发现，Ⅱ级以上 ccRCC 组织中 ATM 的表达低于Ⅱ级或以下。Kaplan-Meier 生存分析显示，ATM 低表达组的总生存时间明显短于 ATM 高表达组。多因素 Cox 回归分析显示，ATM 表达水平和临床分期是影响 ccRCC 预后的独立因素。
ATM 表达水平可作为 ccRCC 预后的独立危险因素，可作为 ccRCC 的潜在治疗靶点。
