Department of Biomedical Engineering, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Department of Radiation Oncology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Ultrasound Med Biol. 2019 May;45(5):1025-1043. doi: 10.1016/j.ultrasmedbio.2018.12.007. Epub 2019 Feb 14.
Hyperthermia therapy (HT) raises tissue temperature to 40-45°C for up to 60 min. Hyperthermia is one of the most potent sensitizers of radiation therapy (RT). Ultrasound-mediated HT for radiosensitization has been used clinically since the 1960s. Recently, magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU), which has been approved by the United States Food and Drug Administration for thermal ablation therapy, has been adapted for HT. With emerging clinical trials using MRgHIFU HT for radiosensitization, there is a pressing need to review the ultrasound HT technology. The objective of this review is to overview existing HT technology, summarize available ultrasound HT devices, evaluate clinical studies combining ultrasound HT with RT and discuss challenges and future directions.
热疗（HT）将组织温度提高到 40-45°C 长达 60 分钟。热疗是放射治疗（RT）最有效的增敏剂之一。自 20 世纪 60 年代以来，超声介导的 HT 已用于临床放射增敏。最近，美国食品和药物管理局已批准磁共振引导高强度聚焦超声（MRgHIFU）用于热消融治疗，现已将其用于 HT。随着越来越多的临床试验采用 MRgHIFU HT 进行放射增敏，迫切需要对超声 HT 技术进行综述。本综述的目的是概述现有的 HT 技术，总结现有的超声 HT 设备，评估将超声 HT 与 RT 相结合的临床研究，并讨论挑战和未来方向。
