Tajiki-Nishino Risako, Watanabe Yuko, Fukuyama Tomoki
The Institute of Environmental Toxicology, 4321, Uchimoriya-machi, Joso-shi, Ibaraki 303-0043, Japan.
Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
J Vet Med Sci. 2019 Apr 16;81(4):541-544. doi: 10.1292/jvms.18-0641. Epub 2019 Feb 15.
The aim of this study is to identify the combined effect of multiple chemicals to the development of allergy. In this study, the effect of prenatal exposure to an organochlorine agent methoxychlor (MXC) and/or an organophosphate agent parathion (PARA) on trimellitic anhydride-induced allergic airway inflammation was examined in mice. Eosinophil infiltration in the bronchoalveolar lavage fluid (BALF) was significantly enhanced by MXC + PARA exposure compared to that of the control, MXC, and PARA groups. In the hilar lymph node, only slight increases in B-cell infiltration, as well as IL-6 and IL-9 secretions were observed in MXC + PARA group, and no effect was observed in the individual treatment groups. Our findings imply that prenatal exposure to some combinations of multiple chemicals may exacerbate the allergic inflammatory responses including eosinophils and cytokine production.
本研究的目的是确定多种化学物质对过敏症发展的综合影响。在本研究中，检测了产前暴露于有机氯剂甲氧滴滴涕（MXC）和/或有机磷剂对硫磷（PARA）对偏苯三酸酐诱导的小鼠过敏性气道炎症的影响。与对照组、MXC组和PARA组相比，MXC + PARA暴露显著增强了支气管肺泡灌洗液（BALF）中的嗜酸性粒细胞浸润。在肺门淋巴结中，MXC + PARA组仅观察到B细胞浸润以及IL-6和IL-9分泌略有增加，而在单独治疗组中未观察到影响。我们的研究结果表明，产前暴露于多种化学物质的某些组合可能会加剧包括嗜酸性粒细胞和细胞因子产生在内的过敏性炎症反应。
