Fardi Masoumeh, Alivand Mohammadreza, Baradaran Behzad, Farshdousti Hagh Majid, Solali Saeed
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunology Department, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cell Physiol. 2019 Sep;234(9):14783-14799. doi: 10.1002/jcp.28277. Epub 2019 Feb 17.
Zinc finger E-box binding homeobox 2 (ZEB2) is a DNA-binding transcription factor, which is mainly involved in epithelial-to-mesenchymal transition (EMT). EMT is a conserved process during which mature and adherent epithelial-like state is converted into a mobile mesenchymal state. Emerging data indicate that ZEB2 plays a pivotal role in EMT-induced processes such as development, differentiation, and malignant mechanisms, for example, drug resistance, cancer stem cell-like traits, apoptosis, survival, cell cycle arrest, tumor recurrence, and metastasis. In this regard, the understanding of mentioned subjects in the development of normal and cancerous cells could be helpful in cancer complexity of diagnosis and therapy. In this study, we review recent findings about the biological properties of ZEB2 in healthy and cancerous states to find new approaches for cancer treatment.
锌指E盒结合同源框蛋白2（ZEB2）是一种DNA结合转录因子，主要参与上皮-间质转化（EMT）。EMT是一个保守过程，在此过程中，成熟且黏附的上皮样状态会转变为可移动的间质状态。新出现的数据表明，ZEB2在EMT诱导的过程中发挥关键作用，如发育、分化和恶性机制，例如耐药性、癌症干细胞样特征、凋亡、存活、细胞周期停滞、肿瘤复发和转移。在这方面，了解正常细胞和癌细胞发育过程中的上述主题，可能有助于癌症诊断和治疗的复杂性研究。在本研究中，我们回顾了关于ZEB2在健康和癌症状态下生物学特性的最新发现，以寻找癌症治疗的新方法。
