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重复经颅磁刺激对脑卒中患者运动功能恢复的影响及最佳参数:一项随机对照试验的系统评价和荟萃分析。

The effect and optimal parameters of repetitive transcranial magnetic stimulation on motor recovery in stroke patients: a systematic review and meta-analysis of randomized controlled trials.

机构信息

1 Department of Rehabilitation Medicine, Chonggang General Hospital, Chongqing, China.

2 Department of Gastrointestinal Neonatal Surgery, Children's Hospital of Chongqing Medical University, Chongqing, China.

出版信息

Clin Rehabil. 2019 May;33(5):847-864. doi: 10.1177/0269215519829897. Epub 2019 Feb 18.


DOI:10.1177/0269215519829897
PMID:30773896
Abstract

OBJECTIVE: The primary aim of this meta-analysis was to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on limb movement recovery post-stroke and cortex excitability, to explore the optimal parameters of rTMS and suitable stroke population. Second, adverse events were also included. DATA SOURCES: The databases of PubMed, EBSCO, MEDLINE, the Cochrane Central Register of Controlled Trials, EBM Reviews-Cochrane Database, the Chinese National Knowledge Infrastructure, and the Chinese Science and Technology Journals Database were searched for randomized controlled trials exploring the effects of rTMS on limb motor function recovery post-stroke before December 2018. REVIEW METHODS: The effect sizes of rTMS on limb motor recovery, the effect size of rTMS stimulation parameters, and different stroke population were summarized by calculating the standardized mean difference (SMD) and the 95% confidence interval using fixed/random effect models as appropriate. RESULTS: For the motor function assessment, 42 eligible studies involving 1168 stroke patients were identified. The summary effect size indicated that rTMS had positive effects on limb motor recovery (SMD = 0.50, P < 0.00001) and activities of daily living (SMD = 0.82, P < 0.00001), and motor-evoked potentials of the stimulated hemisphere differed according to the stimulation frequency, that is, the high-frequency group (SMD = 0.57, P = 0.0006), except the low-frequency group (SMD = -0.27, P = 0.05). No significant differences were observed among the stimulation parameter subgroups except for the sessions subgroup ( P = 0.02). Only 10 included articles reported transient mild discomfort after rTMS. CONCLUSIONS: rTMS promoted the recovery of limb motor function and changed the cortex excitability. rTMS may be better for early and pure subcortical stroke patients. Regarding different stimulation parameters, the number of stimulation sessions has an impact on the effect of rTMS.

摘要

目的:本次荟萃分析的主要目的是评估重复经颅磁刺激(rTMS)对脑卒中后肢体运动恢复和皮层兴奋性的影响,探索 rTMS 的最佳参数和适合的脑卒中人群。其次,还纳入了不良反应事件。

资料来源:检索了 PubMed、EBSCO、MEDLINE、Cochrane 对照试验中心注册库、EBM Reviews-Cochrane 数据库、中国国家知识基础设施和中国科技期刊数据库,以查找截至 2018 年 12 月探索 rTMS 对脑卒中后肢体运动功能恢复影响的随机对照试验。

综述方法:采用固定/随机效应模型计算标准化均数差(SMD)和 95%置信区间,总结 rTMS 对肢体运动恢复的效应量、rTMS 刺激参数的效应量以及不同脑卒中人群的效应量。

结果:针对运动功能评估,共纳入 42 项符合条件的研究,涉及 1168 例脑卒中患者。汇总效应量表明 rTMS 对肢体运动恢复(SMD=0.50,P<0.00001)和日常生活活动(SMD=0.82,P<0.00001)均有积极影响,且刺激半球的运动诱发电位因刺激频率而异,即高频组(SMD=0.57,P=0.0006),除低频组(SMD=-0.27,P=0.05)外。除疗程亚组(P=0.02)外,各刺激参数亚组间未见显著差异。仅有 10 篇纳入文献报道 rTMS 后出现短暂轻度不适。

结论:rTMS 促进了肢体运动功能的恢复,并改变了皮层兴奋性。rTMS 可能更适合早期和单纯皮质下脑卒中患者。对于不同的刺激参数,刺激次数对 rTMS 的效果有影响。

相似文献

[1]
The effect and optimal parameters of repetitive transcranial magnetic stimulation on motor recovery in stroke patients: a systematic review and meta-analysis of randomized controlled trials.

Clin Rehabil. 2019-2-18

[2]
Short- and Long-term Effects of Repetitive Transcranial Magnetic Stimulation on Upper Limb Motor Function after Stroke: a Systematic Review and Meta-Analysis.

Clin Rehabil. 2017-2-17

[3]
Repetitive transcranial magnetic stimulation of lower limb motor function in patients with stroke: a systematic review and meta-analysis of randomized controlled trials.

Clin Rehabil. 2019-3-13

[4]
Effects of repetitive transcranial magnetic stimulation on motor functions in patients with stroke: a meta-analysis.

Stroke. 2012-6-19

[5]
Repetitive transcranial magnetic stimulation for improving function after stroke.

Cochrane Database Syst Rev. 2013-5-31

[6]
Excitatory Repetitive Transcranial Magnetic Stimulation Over the Ipsilesional Hemisphere for Upper Limb Motor Function After Stroke: A Systematic Review and Meta-Analysis.

Front Neurol. 2022-6-20

[7]
Low-Frequency Repetitive Transcranial Magnetic Stimulation for Stroke-Induced Upper Limb Motor Deficit: A Meta-Analysis.

Neural Plast. 2017-12-21

[8]
Effects of coupling inhibitory and facilitatory repetitive transcranial magnetic stimulation on motor recovery in patients following acute cerebral infarction.

NeuroRehabilitation. 2021

[9]
[Effects of repetitive transcranial magnetic stimulation on upper limb motor function in patients with stroke: a meta analysis].

Zhonghua Yi Xue Za Zhi. 2017-12-19

[10]
The effect and optimal parameters of repetitive transcranial magnetic stimulation on lower extremity motor function in stroke patient: a systematic review and meta-analysis.

Disabil Rehabil. 2024-10

引用本文的文献

[1]
Effects of electrical and magnetic stimulation on upper extremity function after stroke: A systematic review and network meta-analysis.

PM R. 2025-8

[2]
Therapeutic Intervention for Trunk Control Impairments in Central Nervous System Disorders: A Comprehensive Review of Methods and Efficacy.

Prog Rehabil Med. 2025-1-16

[3]
Clinical implementation, barriers, and unmet needs of rTMS and neuro-navigation systems in stroke rehabilitation: a nationwide survey in South Korea.

Front Neurol. 2024-7-30

[4]
The Simultaneous Application of Transcranial Magnetic Stimulation and Virtual Reality to Treat Cognitive Deficits Among Stroke Patients: A Randomized Controlled Trial.

Cureus. 2024-6-15

[5]
Transcranial magnetic stimulation as a countermeasure for behavioral and neuropsychological risks of long-duration and deep-space missions.

NPJ Microgravity. 2024-5-28

[6]
Theta burst stimulation for enhancing upper extremity motor functions after stroke: a systematic review of clinical and mechanistic evidence.

Rev Neurosci. 2024-8-27

[7]
Changes in Structural Neural Networks in the Recovery Process of Motor Paralysis after Stroke.

Brain Sci. 2024-2-21

[8]
Repetitive peripheral magnetic stimulation combined with transcranial magnetic stimulation in rehabilitation of upper extremity hemiparesis following stroke: a pilot study.

J Rehabil Med. 2024-2-1

[9]
Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined with Psychological Interventions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Brain Sci. 2023-11-30

[10]
The effects of rTMS on motor recovery after stroke: a systematic review of fMRI studies.

Neurol Sci. 2024-3

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