Graduate School, University of Santo Tomas, Manila, Philippines.
Tiniguiban Heights, Palawan State University, Puerto Princesa City, Philippines.
Nat Prod Res. 2020 Apr;34(8):1175-1179. doi: 10.1080/14786419.2018.1550759. Epub 2019 Feb 17.
Coronaridine () was isolated from the CHCl root extract of The structure of was established from 1D- and 2D-NMR and HR-ESIMS experiments, and by comparison with reported spectroscopic data. To date, this is the first report of compound from introduced as new species from Philippines in 2005 on the basis of morphological characters. Coronaridine, an iboga-type indole alkaloid, has been isolated from over 50 species and can thus be inferred as a chemotaxonomic marker of the genus. has a distinct arrangement of leaves not known in the genus, but is variable in other genera. Its isolation from endemic establishes its position in the genus and supports the claim that coronaridine is a chemical marker of the genus Interestingly, coronaridine exhibited relatively weak activity against HRv (MIC 82.64 μg/mL) (Rifampicin MIC 0.05 μg/mL).
冠蕊木因（）从 CHCl 根提取物中分离出来。结构通过 1D 和 2D-NMR 和 HR-ESIMS 实验以及与报道的光谱数据进行比较来建立，迄今为止，这是首次从菲律宾于 2005 年作为新种（）中分离出化合物，其基于形态特征。冠蕊木因是一种伊波加型吲哚生物碱，已从 50 多种物种中分离出来，因此可以推断其是该属的化学生物标记物。该属的叶子排列独特，在其他属中则不同。从特有种中分离出它，确立了它在属中的地位，并支持了冠蕊木因是该属化学标记物的说法。有趣的是，冠蕊木因对 HRv 的活性相对较弱（MIC82.64μg/mL）（利福平 MIC0.05μg/mL）。
