[The catalytic subunit of the anaphase-promoting complex, APC11, is involved in CIN CRC progression]. - Suppr | 超能文献

[The catalytic subunit of the anaphase-promoting complex, APC11, is involved in CIN CRC progression].

作者信息

Moyret-Lalle Caroline, Drouet Youenn, Puisieux Alain

机构信息

Inserm U1052, CNRS UMR 5286, Cancer research center of Lyon, Lyon, F-69008, France - Centre Léon Bérard, 28, rue Laënnec, Lyon, F-69008, France - Université Lyon1, ISPB, Lyon, F-69008, France - Université de Lyon, Lyon, F-69622, France - LabEx DEVweCAN, Université de Lyon, F-69000 Lyon, France.

Centre Léon Bérard, Département de santé publique, 28, rue Laënnec, Lyon, F-69008, France - CNRS UMR 5558, Laboratoire de biométrie et biologie évolutive, Lyon, F-69373, France.

出版信息

Med Sci (Paris). 2019 Feb;35(2):118-122. doi: 10.1051/medsci/2019020. Epub 2019 Feb 18.

DOI:10.1051/medsci/2019020

Abstract

摘要

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[The catalytic subunit of the anaphase-promoting complex, APC11, is involved in CIN CRC progression].

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Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer.综合分析突出 APC11 蛋白表达可能是结直肠癌新的独立预测标志物。

Sci Rep. 2018 May 9;8(1):7386. doi: 10.1038/s41598-018-25631-1.

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APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.APC2 泛素连接酶蛋白和 APC11 环状蛋白构成了后期促进复合体的最小泛素连接酶模块。

Mol Biol Cell. 2001 Dec;12(12):3839-51. doi: 10.1091/mbc.12.12.3839.

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RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.人类后期促进复合体中泛素连接到无序底物的RING E3机制可视化

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5272-9. doi: 10.1073/pnas.1504161112. Epub 2015 Mar 30.

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.ROC1 是 APC11 的同源物，代表具有相关泛素连接酶活性的一类cullin蛋白伴侣。

Mol Cell. 1999 Apr;3(4):535-41. doi: 10.1016/s1097-2765(00)80482-7.

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The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex.环状H2指蛋白APC11和E2酶UBC4足以使后期促进复合物的底物泛素化。

Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8973-8. doi: 10.1073/pnas.97.16.8973.

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TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.后期促进复合物的TPR亚基介导与激活蛋白CDH1的结合。

Curr Biol. 2003 Sep 2;13(17):1459-68. doi: 10.1016/s0960-9822(03)00581-5.

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The RING-H2-finger protein APC11 as a target of hydrogen peroxide.具有RING-H2结构域的泛素连接酶APC11作为过氧化氢的作用靶点。

Free Radic Biol Med. 2004 Aug 15;37(4):521-30. doi: 10.1016/j.freeradbiomed.2004.05.006.

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The APC11 RING-H2 finger mediates E2-dependent ubiquitination.APC11的RING-H2结构域介导E2依赖性泛素化。

Mol Biol Cell. 2000 Jul;11(7):2315-25. doi: 10.1091/mbc.11.7.2315.

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Knockdown expression of Apc11 leads to cell-cycle distribution reduction in G2/M phase.

Genet Mol Res. 2012 Aug 24;11(3):2814-22. doi: 10.4238/2012.August.24.6.

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