Bareeqa Syeda Beenish, Bibi Fazeela, Ahmed Syed Ijlal, Samar Syeda Sana
Jinnah Medical and Dental College, Karachi, Pakistan.
Medical Graduate, Liaquat National Medical College and Hospital, Karachi, Pakistan.
Int J Hematol Oncol Stem Cell Res. 2018 Oct 1;12(4):282-290.
Cardiac muscle possesses a limited capacity to regenerate its tissue on its own. It is less likely to reverse the altered cardiac functioning to its normal physiological state after a major myocardial infarction. Stem cell transplantation provided a unique therapeutic approach in managing such injuries. There has been a substantial debate about the complexity, scope and medical application of stem cell transplantation in past few years. An extensive review of medical literature was conducted to establish the consensus about the possible mechanism of cell renewal, associated complications and risks of failure of this technique. Twenty cases of mammalian animals and twenty-four cases of stem cell transplantation in human subjects were reviewed. Most common associated complication was re-stenosis of coronary artery. Few clinical trials reported the failure in improving cardiac functioning. The success rate of stem cell transplantation was remarkable in the literature related to experimental animal subjects. It was concluded that renewal of the cardiac cell is a result of induction of angiogenesis and prolonged cell survival. This topic still requires an immense amount of research to fill the gap in adequate knowledge.
心肌自身再生其组织的能力有限。在发生重大心肌梗死后，心脏功能恢复到正常生理状态的可能性较小。干细胞移植为处理此类损伤提供了一种独特的治疗方法。在过去几年里，关于干细胞移植的复杂性、范围和医学应用存在大量争论。为了就细胞更新的可能机制、相关并发症以及该技术失败的风险达成共识，对医学文献进行了广泛的综述。回顾了20例哺乳动物动物实验和24例人类受试者的干细胞移植案例。最常见的相关并发症是冠状动脉再狭窄。很少有临床试验报告在改善心脏功能方面失败。在与实验动物相关的文献中，干细胞移植的成功率显著。得出的结论是，心脏细胞的更新是血管生成诱导和细胞长期存活的结果。这个主题仍需要大量研究来填补足够知识方面的空白。
