Hemalatha Anupama, Mayor Satyajit
Department of Genetics, Yale School of Medicine, New Haven, CT, 06511, USA.
National Centre for Biological Sciences (NCBS-TIFR), Bangalore, Karnataka, 560065, India.
F1000Res. 2019 Jan 31;8. doi: 10.12688/f1000research.16549.1. eCollection 2019.
Endocytic pathways are broadly classified into clathrin dependent and independent on the basis of the requirement for the coat protein, clathrin. The molecular pathways and mechanisms underlying the formation of clathrin-independent pathways are still being explored, and this review summarizes recent advances and emerging functional roles of these diverse pathways. In particular, this review will discuss the growing consensus on the role of BAR domain proteins and the actin machinery in different clathrin-independent pathways and its significance to the functions fulfilled by these endocytic pathways.
根据对包被蛋白网格蛋白的需求,内吞途径大致分为依赖网格蛋白的和不依赖网格蛋白的。不依赖网格蛋白途径形成的分子途径和机制仍在探索中,本综述总结了这些不同途径的最新进展和新出现的功能作用。特别是,本综述将讨论关于BAR结构域蛋白和肌动蛋白机制在不同不依赖网格蛋白途径中的作用的日益增长的共识,以及其对这些内吞途径所履行功能的意义。