Janz Tyler A, Neskey David M, Nguyen Shaun A, Lentsch Eric J
Medical University of South Carolina, 135 Rutledge Ave., Charleston, SC., 29425, USA.
World J Otorhinolaryngol Head Neck Surg. 2018 Aug 11;5(1):34-40. doi: 10.1016/j.wjorl.2018.05.006. eCollection 2019 Mar.
To provide an understanding of the incidence of anaplastic thyroid cancer within the United States.
Patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of anaplastic thyroid cancer using ICD O-3 codes. Patients were categorized into cohorts based on their year of diagnosis.
1527 patients were diagnosed with anaplastic thyroid cancer within the SEER 18 registries. The age-adjusted incidence rate was 0.2 per 1,000,000 people (95% : 0.0-0.5) in 1973 and was 1.2 per 1,000,000 people (95% : 0.8-1.6) in 2014 (average annual percent change: 3.0% [95% : 2.2%-3.7%]). Patients tended to be of older age (mean age: 70.5 [range 15.0-102.0]), of female sex (62.8%), and Caucasian (81.1%). Finally, survival over time remained the same, as median disease specific survival months was 4.00 (95% : 2.26-5.74) from 1995 to 1999 and 4.00 (95% : 3.26-4.74) from 2010 to 2014.
The incidence rate of anaplastic thyroid cancer has increased from 1973 to 2014. Interestingly, median survival in months did not greatly change overtime. Based on this increasing incidence, physicians must act appropriately to identify patients with anaplastic thyroid cancer as it possesses a high morbidity and mortality.
了解美国间变性甲状腺癌的发病率。
根据国际疾病分类肿瘤学第三版（ICD O - 3）编码诊断为间变性甲状腺癌，纳入监测、流行病学和最终结果（SEER）数据库中1973年至2014年的患者。根据诊断年份将患者分为不同队列。
在SEER的18个登记处，有1527例患者被诊断为间变性甲状腺癌。1973年年龄调整后的发病率为每100万人0.2例（95%置信区间：0.0 - 0.5），2014年为每100万人1.2例（95%置信区间：0.8 - 1.6）（年均变化百分比：3.0% [95%置信区间：2.2% - 3.7%]）。患者倾向于年龄较大（平均年龄：70.5岁[范围15.0 - 102.0岁]），女性（62.8%），白种人（81.1%）。最后，随着时间推移生存率保持不变，1995年至1999年疾病特异性生存月中位数为4.00（95%置信区间：2.26 - 5.74），2010年至2014年为4.00（95%置信区间：3.26 - 4.74）。
1973年至2014年间变性甲状腺癌的发病率有所上升。有趣的是，生存月中位数随时间变化没有太大改变。基于这种发病率的上升，医生必须采取适当行动来识别间变性甲状腺癌患者，因为该病具有高发病率和高死亡率。
4级。
