Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Department of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.
Dalton Trans. 2019 Mar 14;48(10):3193-3197. doi: 10.1039/c9dt00259f. Epub 2019 Feb 18.
Previous studies on the neutral and cationic half-sandwich iridium(iii) and ruthenium(ii) complexes showed that the charge and the substitution pattern of the bidentate ligands, as well as the nature of the accompanying counteranion have a significant effect on their biological activities. In this contribution, a series of zwitterionic and cationic half-sandwich iridium(iii) and ruthenium(ii) complexes containing sulfonate groups have been prepared and characterized. The different locations of counteranions between these two kinds of complexes exert great influence on the cytotoxic activity towards cancer cells. The various possible mechanism of actions (MoAs) of the complexes were determined by flow cytometry. This work has shown for the first time the different biological activities between zwitterionic and cationic half-sandwich complexes.
先前关于中性和阳离子半三明治铱(III)和钌(II)配合物的研究表明，双齿配体的电荷和取代模式以及伴随的抗衡阴离子的性质对它们的生物活性有显著影响。在本贡献中，制备并表征了一系列含有磺酸根基团的两性离子和阳离子半三明治铱(III)和钌(II)配合物。这两种配合物中抗衡阴离子的不同位置对癌细胞的细胞毒性有很大影响。通过流式细胞术确定了配合物的各种可能作用机制 (MoAs)。这项工作首次表明了两性离子和阳离子半三明治配合物之间的不同生物活性。
