Er Tze-Kiong, Su Yu-Fa, Chan Tzu-Hsien
Clin Lab. 2019 Jan 1;65(1). doi: 10.7754/Clin.Lab.2018.180626.
The aim of this study was to compare the validity of two different cTnI assay methodologies.
We collected 82 plasma samples from a stat laboratory. The plasma values of cTnI ranged from 0.012 to 29.715 ng/mL when tested on the Access® platform and from 4.5 to >40,000 ng/L when tested on the VIDAS platform. The patients included 34 females ranging in age from 49 to 100 years of age [76.7 ± 12 years] and 48 males ranging from 29 to 97 years of age [69.7 ± 12 years].
Our results showed that the correlation between the two troponin results was r2 = 0.9836 (p < 0.001). In this study, the kappa statistic (0.89) indicated a high degree of agreement between the VIDAS® High-sensitivity Troponin I assay and the Beckman Coulter Unicel® DXI AccuTnI+3 assay.
In summary, the VIDAS® High-sensitivity Troponin I assay is a reliable and feasible method for determining the levels of cTnI in plasma, but it requires manual operation, hands-on technical expertise, and time.
本研究的目的是比较两种不同的肌钙蛋白I（cTnI）检测方法的有效性。
我们从一家急诊实验室收集了82份血浆样本。在Access®平台上检测时，血浆中cTnI的值范围为0.012至29.715 ng/mL，在VIDAS平台上检测时为4.5至>40,000 ng/L。患者包括34名女性，年龄在49至100岁之间[76.7±12岁]，48名男性，年龄在29至97岁之间[69.7±12岁]。
我们的结果显示，两种肌钙蛋白检测结果之间的相关性为r2 = 0.9836（p < 0.001）。在本研究中，kappa统计量（0.89）表明VIDAS®高敏肌钙蛋白I检测法与贝克曼库尔特Unicel® DXI AccuTnI+3检测法之间具有高度一致性。
总之，VIDAS®高敏肌钙蛋白I检测法是一种可靠且可行的测定血浆中cTnI水平的方法，但它需要人工操作、实际操作技术专长和时间。
