School of Biosciences & Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK.
Microbiology (Reading). 2019 Apr;165(4):386-395. doi: 10.1099/mic.0.000783. Epub 2019 Feb 18.
Regulatory interactions at the lac promoter.Activation of the transcription of genes is central to many processes of adaptation and differentiation in bacteria. Here, I review the molecular mechanisms by which transcription factors can activate the initiation of specific transcripts at bacterial promoters. The story is presented in the context of Marjory Stephenson's pioneering work on enzymatic adaptation in bacteria, and sets the different mechanisms in the greater context of how transcription regulatory mechanisms evolved.
调控相互作用在 lac 启动子。基因转录的激活是细菌适应和分化的许多过程的核心。在这里，我回顾了转录因子可以激活细菌启动子特定转录物起始的分子机制。这个故事是在 Marjory Stephenson 关于细菌酶适应性的开创性工作的背景下呈现的，并将不同的机制置于转录调控机制如何进化的更大背景下。
