Sleep-Wake-Epilepsy Center and Center for Experimental Neurology, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland; Wyss Center for Bio and Neuro-engineering, Geneva, Switzerland.
Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Exp Neurol. 2019 May;315:82-87. doi: 10.1016/j.expneurol.2019.02.006. Epub 2019 Feb 15.
Recent trials of chronic EEG in humans showed that epilepsy is a cyclical disorder of the brain with rhythms at multiple time-scales: circadian, multi-day (multidien) or even seasonal. Here, we analyzed chronic EEG data (>30 days) in male epileptic rats and unraveled not only circadian but also, slower, multidien rhythms of interictal epileptiform activity with periodicity of about 2-3 and 5-7 days. Importantly, seizures were not uniformly distributed over time, but rather clustered at preferential phases of these underlying rhythms, delineating critical circadian times and multidien phase of heightened seizure risk. Multidien rhythms were not synchronous across animals or with human intervention suggesting an endogenous generator. In epilepsy, across species, unknown factors modulate seizure timing in cyclical patterns over multiple days.
最近的人类慢性 EEG 试验表明，癫痫是一种大脑周期性障碍，具有多个时间尺度的节律：昼夜节律、多天（多日）甚至季节性。在这里，我们分析了雄性癫痫大鼠的慢性 EEG 数据（>30 天），不仅揭示了昼夜节律，还揭示了较慢的、多天的癫痫样活动的间发性节律，其周期性约为 2-3 天和 5-7 天。重要的是，癫痫发作并不是均匀分布在时间上的，而是集中在这些潜在节律的优先阶段，划定了关键的昼夜时间和癫痫发作风险增加的多天阶段。多天节律在动物之间或与人类干预并不同步，这表明存在内源性发生器。在癫痫中，跨物种的未知因素以周期性模式在多天内调节发作时间。
