Griffith Institute for Drug Discovery and School of Environment and Science, Griffith University, Nathan, 4111, QLD, Australia.
Chem Biol Interact. 2019 Apr 25;303:22-26. doi: 10.1016/j.cbi.2019.01.023. Epub 2019 Feb 15.
Bioinformatic analyses of salmon (Salmo salar) ALDH amino acid sequences supported the presence of at least 30 ALDH genes, which is more than for any other higher vertebrate and is greater than the 19 human ALDH genes currently reported. These included 8 polyploid ALDH genes and proteins: ALDH1A2 (chromosomes 11 and 26); ALDH1L2 (chromosomes 7 and 17); ALDH2, encoding mitochondrial ALDH2 (chromosomes 2 and 5); ALDH3A2 (chromosomes 4, 9 and 20), for which evidence for 5 genes was obtained; ALDH3B1 (chromosomes 3, 6 and 24); ALDH4A1 (chromosomes 12 and 22); ALDH6A1 (chromosomes 1, 6 and 15); and ALDH18A1 (chromosomes 19 and 28). In contrast, 7 salmon ALDH gene families (ALDH1A1, ALDH1A3, ALDH5, ALDH7, ALDH8, ALDH9 and ALDH16) possessed only one gene family member. Phylogenetic studies of salmon and rainbow trout ALDH3A2 genes and proteins suggested that salmonid gene tetraploidy has occurred in at least 2 distinct stages of ALDH3A2 gene evolution.
对三文鱼（Salmo salar）ALDH 氨基酸序列的生物信息学分析支持至少存在 30 个 ALDH 基因，这比任何其他高等脊椎动物都多，也超过了目前报道的 19 个人类 ALDH 基因。其中包括 8 个多倍体 ALDH 基因和蛋白质：ALDH1A2（染色体 11 和 26）；ALDH1L2（染色体 7 和 17）；编码线粒体 ALDH2 的 ALDH2（染色体 2 和 5）；ALDH3A2（染色体 4、9 和 20），其中获得了 5 个基因的证据；ALDH3B1（染色体 3、6 和 24）；ALDH4A1（染色体 12 和 22）；ALDH6A1（染色体 1、6 和 15）；和 ALDH18A1（染色体 19 和 28）。相比之下，7 个三文鱼 ALDH 基因家族（ALDH1A1、ALDH1A3、ALDH5、ALDH7、ALDH8、ALDH9 和 ALDH16）只拥有一个基因家族成员。对三文鱼和虹鳟鱼 ALDH3A2 基因和蛋白质的系统发育研究表明，鲑鱼科的基因四倍体至少在 ALDH3A2 基因进化的 2 个不同阶段发生过。
