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用抗胸腺细胞球蛋白成功治疗活体供肾肾移植相关血栓性微血管病:一例报告

Living-Donor Kidney Transplant-Associated Thrombotic Microangiopathy Successfully Treated With Thymoglobulin: A Case Report.

作者信息

Akl Ahmed, Alobaidi Sami, Aboalsamh Ghaleb

机构信息

From the Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia; and the Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

出版信息

Exp Clin Transplant. 2019 Jan;17(Suppl 1):175-177. doi: 10.6002/ect.MESOT2018.P51.

Abstract

Transplantation is the ultimate therapy for end-stage kidney disease. Early graft dysfunction is a devastating event to patients and carries risk of graft loss. Medical causes of early graft loss include graft rejection, drug toxicity, and thrombotic microangiopathy. Here, we report a case of posttransplant thrombotic microangiopathy associated with cellular vascular rejection. Thymoglobulin successfully reversed vascular rejection and thrombotic microangiopathy associated with half dosing of calcineurin inhibitors.

摘要

移植是终末期肾病的最终治疗方法。早期移植肾功能障碍对患者来说是一个毁灭性事件,并伴有移植肾丢失的风险。早期移植肾丢失的医学原因包括移植肾排斥反应、药物毒性和血栓性微血管病。在此,我们报告一例与细胞性血管排斥反应相关的移植后血栓性微血管病病例。胸腺球蛋白成功逆转了与半量使用钙调神经磷酸酶抑制剂相关的血管排斥反应和血栓性微血管病。

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