无烟烟草的致癌性：来自人类和实验动物研究的证据。
Carcinogenicity of smokeless tobacco: Evidence from studies in humans & experimental animals.
机构信息
WHO Collaborating Centre for Oral Cancer, King's College London, London, UK.
Section of Evidence Synthesis and Classification, International Agency for Research on Cancer, Lyon, France.
出版信息
Indian J Med Res. 2018 Dec;148(6):681-686. doi: 10.4103/ijmr.IJMR_149_18.
A Working Group of the Monographs programme of the International Agency for Research on Cancer has classified smokeless tobacco as carcinogenic to humans (Group 1). This review article summarizes the data that support the evaluations of sufficient evidence in humans and in experimental animals for the carcinogenicity of smokeless tobacco whether used alone or with betel quid. It also identifies compounds of smokeless tobacco relevant to carcinogenicity (prominently tobacco-specific nitrosamines) and addiction (nicotine). The epidemiological evidence is summarized for oral cancer, other cancers associated with smokeless tobacco and oral potentially malignant lesions with a focus on analytical studies from the SEARO Region. Studies on cancer in experimental animals are summarized with a focus on studies applying smokeless tobacco products typical for the regions, such as mishri and naswar.
国际癌症研究机构专著计划工作组已将无烟烟草归类为人类致癌物质（第 1 组）。本文综述了支持无烟烟草致癌性评估的证据，这些证据包括人类和实验动物中使用单独使用或与槟榔一起使用的无烟烟草是否具有足够的致癌证据。还确定了与致癌性（主要是烟草特异性亚硝胺）和成瘾性（尼古丁）相关的无烟烟草化合物。总结了口腔癌、与无烟烟草相关的其他癌症以及口腔潜在恶性病变的流行病学证据，重点是来自东南亚和西太平洋地区的分析性研究。还总结了实验动物癌症的研究情况，重点是应用该地区典型的无烟烟草制品的研究，如 mishri 和 naswar。
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