Department of Pathology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cell Physiol. 2019 Aug;234(10):16861-16872. doi: 10.1002/jcp.28368. Epub 2019 Feb 19.
microRNAs (miRNAs) are known as a large group of short noncoding RNAs, which structurally consist of 19-22 nucleotides in length and functionally act as one of the main regulators of gene expression in important biological and physiological contexts like cell growth, apoptosis, proliferation, differentiation, movement (cell motility), and angiogenesis as well as disease formation and progression importantly in cancer cell invasion, migration, and metastasis. Among these notable tiny molecules, many studies recently presented the important role of the miR-193 family comprising miR-193a-3p, miR-193a-5p, miR-193b-3p, and miR-193b-5p in health and disease biological processes by interaction with special targeting and signaling, which mainly contribute as a tumor suppressor. Therefore, in the present paper, we review the functional role of this miRNA family in both health and disease conditions focusing on various tumor developments, diagnoses, prognoses, and treatment.
微小 RNA（miRNAs）是一类长约 19-22 个核苷酸的短非编码 RNA，作为重要生物学和生理学过程（如细胞生长、凋亡、增殖、分化、运动（细胞迁移）和血管生成）以及疾病形成和进展（尤其是在癌症细胞侵袭、迁移和转移中）的主要基因表达调控因子之一。在这些引人注目的微小分子中，最近有许多研究表明，miR-193 家族（包括 miR-193a-3p、miR-193a-5p、miR-193b-3p 和 miR-193b-5p）在与特定靶向和信号的相互作用下，通过与特殊靶向和信号的相互作用，在健康和疾病的生物学过程中发挥着重要作用，主要作为肿瘤抑制因子。因此，在本文中，我们综述了该 miRNA 家族在健康和疾病条件下的功能作用，重点关注各种肿瘤的发展、诊断、预后和治疗。
