进化：诱饵受体作为对抗病原体的独特武器。

Evolution: Decoy Receptors as Unique Weapons to Fight Pathogens.

机构信息

Tumor Immunology Laboratory, LIFE Center, Ludwig-Maximilians-University of Munich, 81377 Munich, Germany.

出版信息

Curr Biol. 2019 Feb 18;29(4):R128-R130. doi: 10.1016/j.cub.2018.12.006.

DOI:10.1016/j.cub.2018.12.006

Abstract

Many pathogens must bind to entry receptors on the surfaces of host cells yet avoid any closely-related phagocytic decoy receptors on granulocytes that evolved as a host defense mechanism. The discovery of decoy-receptor polymorphisms in human populations now points to an evolutionary process that allows the host to catch up with pathogens.

摘要

许多病原体必须与宿主细胞表面的进入受体结合，但要避免与作为宿主防御机制进化而来的粒细胞上任何密切相关的吞噬性诱饵受体结合。人类群体中诱饵受体多态性的发现，现在指向了一个允许宿主赶上病原体的进化过程。