Campbell Allison A, Wisco Blair E, Silvia Paul J, Gay Natalie G
The Department of Psychology, The University of North Carolina at Greensboro, 296 Eberhart Bldg, PO Box 26170, Greensboro, 26170, United States.
The Department of Psychology, The University of North Carolina at Greensboro, 296 Eberhart Bldg, PO Box 26170, Greensboro, 26170, United States.
Biol Psychol. 2019 May;144:125-135. doi: 10.1016/j.biopsycho.2019.02.005. Epub 2019 Feb 16.
Respiratory sinus arrhythmia (RSA) has been examined as a psychophysiological marker of stress vulnerability. Research indicates that low resting RSA is associated with physical and mental health problems, including posttraumatic stress disorder (PTSD). Some research suggests that people diagnosed with PTSD have lower RSA than people without PTSD, but findings have been mixed and the overall magnitude of this effect is unknown, indicating the need for a comprehensive meta-analysis. This meta-analysis examined the association between PTSD and baseline RSA in 55 studies, including 12 unpublished studies, with a total sample size of 6689. Studies were included if they used a PTSD measure, a baseline measure of RSA, and involved humans. Studies were excluded if they were not available in English, did not present quantitative data, presented duplicate data, were a case series, or did not provide results required for computing an effect size. The meta-analysis indicated there is a small but significant association between PTSD and RSA (g = -0.26; 95% CI = -0.35, -0.16) with moderate heterogeneity. Moderator analyses suggested that effects are larger for adults than for children and for DSM-5 PTSD measures than for non-DSM referenced measures. We found some evidence for publication bias among the meta-analysis findings. Overall, there is a small but reliable association between PTSD and lower resting RSA, providing support for further research examining the complex relationship between parasympathetic activity and PTSD.
呼吸性窦性心律不齐（RSA）已被作为应激易感性的心理生理指标进行研究。研究表明，静息RSA较低与身心健康问题相关，包括创伤后应激障碍（PTSD）。一些研究表明，被诊断为PTSD的人比未患PTSD的人RSA更低，但研究结果不一，且这种效应的总体程度尚不清楚，这表明需要进行全面的荟萃分析。这项荟萃分析在55项研究中考察了PTSD与基线RSA之间的关联，其中包括12项未发表的研究，总样本量为6689。如果研究使用了PTSD测量方法、RSA的基线测量方法且涉及人类，则纳入研究。如果研究没有英文版本、未呈现定量数据、呈现重复数据、是病例系列研究或未提供计算效应量所需的结果，则将其排除。荟萃分析表明，PTSD与RSA之间存在小但显著的关联（g = -0.26；95%置信区间 = -0.35，-0.16），异质性适中。调节因素分析表明，成人的效应大于儿童，使用《精神疾病诊断与统计手册》第5版（DSM-5）的PTSD测量方法的效应大于未参考DSM的测量方法。我们在荟萃分析结果中发现了一些发表偏倚的证据。总体而言，PTSD与较低的静息RSA之间存在小但可靠的关联，为进一步研究副交感神经活动与PTSD之间的复杂关系提供了支持。
