Gao Liang, Lin Xin-Zhu, Wu Qian-Qian, Lin Yu-Cong, Hong Kun-Yao
Department of Neonatology, Xiamen Maternal and Child Health Care Hospital, Xiamen, Fujian 361000, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2019 Feb;21(2):120-124. doi: 10.7499/j.issn.1008-8830.2019.02.003.
To study the correlation between coagulation function and gestational age in preterm infants and the possible value of coagulation function measurement in predicting hemorrhagic diseases.
The clinical data of preterm infants who were hospitalized between September 2016 and August 2017 were collected. The coagulation indicators were measured within 2 hours after birth. According to the gestational age, the preterm infants were divided into late preterm infant group (n=322), early preterm infant group (n=241) and extremely/very early preterm infant group (n=128). Coagulation function was compared among the three groups, as well as between the preterm infants with and without hemorrhagic diseases within 3 days after birth.
There were significant differences in thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen degradation product (FDP) and D-dimer (DD) among the three groups (P<0.05). APTT, PT, FDP and DD were negatively correlated with gestational age, while TT was positively correlated with gestational age (P<0.05). The preterm infants with hemorrhagic diseases had a longer APTT and a higher level of DD (P<0.05).
Coagulation function gradually becomes mature in preterm infants with the increase in gestational age. Abnormal APTT and DD indicate that preterm infants may have a higher risk of hemorrhagic diseases.
探讨早产儿凝血功能与胎龄的相关性以及凝血功能检测在预测出血性疾病方面的可能价值。
收集2016年9月至2017年8月住院的早产儿临床资料。出生后2小时内检测凝血指标。根据胎龄，将早产儿分为晚期早产儿组（n = 322）、早期早产儿组（n = 241）和极早早产儿组（n = 128）。比较三组之间以及出生后3天内有和无出血性疾病的早产儿之间的凝血功能。
三组之间的凝血酶时间（TT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原降解产物（FDP）和D - 二聚体（DD）存在显著差异（P < 0.05）。APTT、PT、FDP和DD与胎龄呈负相关，而TT与胎龄呈正相关（P < 0.05）。有出血性疾病的早产儿APTT较长，DD水平较高（P < 0.05）。
随着胎龄增加，早产儿凝血功能逐渐成熟。APTT和DD异常表明早产儿可能有较高的出血性疾病风险。
