[下呼吸道感染儿童支气管肺泡灌洗术中的病原体]

[Pathogens in bronchoalveolar lavage fluid of children with lower respiratory tract infection].

作者信息

Guo Ya-Lin, Yang Yu-Xia, Dong Peng-Peng

机构信息

Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2019 Feb;21(2):144-149. doi: 10.7499/j.issn.1008-8830.2019.02.007.

DOI:10.7499/j.issn.1008-8830.2019.02.007

PMID:30782276

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7389829/

Abstract

OBJECTIVE

To study the features of pathogens in children with lower respiratory tract infection.

METHODS

A total of 108 children who were hospitalized due to lower respiratory tract infection and underwent fiber bronchoscopy between January 2017 and June 2018 were enrolled. Bronchoalveolar lavage fluid samples were collected. Multiple quantitative real-time PCR was performed to detect pathogens.

RESULTS

Of the108 children, 85 (78.7%) were found to have pathogens, among whom 52 (48.1%) had single pathogen infection and 33 (30.6%) had multiple pathogen infections. Mycoplasma pneumoniae was detected in 38 children (35.2%), and was the most common pathogen. The children aged 36 - <72 months had the highest detection rate of Mycoplasma pneumoniae. Both Streptococcus pneumoniae and Haemophilus influenzae were detected in 29 children (26.9%) and Streptococcus pneumoniae was mainly detected in children aged <24 months. Each of Acinetobacter baumannii, Candida albicans and Klebsiella pneumoniae was detected in 3 children. Among the 31 children with bronchopneumonia, 9 were found to have Haemophilus influenza, with the highest detection rate of 29%. Among the 34 children with lobar pneumonia, 22 were found to have Mycoplasma pneumoniae, with the highest detection rate of 65%. Among the 22 children with bronchial foreign bodies and bronchopneumonia, 10 were found to have Streptococcus pneumoniae, with the highest detection rate of 45%.

CONCLUSIONS

In children with lower respiratory tract infection, Mycoplasma pneumoniae is the most common pathogen, followed by Streptococcus pneumoniae and Haemophilus influenzae. There are differences in the detection rates of pathogens between children with different ages and different types of lower respiratory tract infection.

摘要

目的

研究下呼吸道感染患儿的病原体特征。

方法

选取2017年1月至2018年6月因下呼吸道感染住院并接受纤维支气管镜检查的108例患儿。采集支气管肺泡灌洗液样本。采用多重定量实时聚合酶链反应检测病原体。

结果

108例患儿中，85例（78.7%）检测出病原体，其中52例（48.1%）为单一病原体感染，33例（30.6%）为多重病原体感染。38例患儿（35.2%）检测出肺炎支原体，为最常见病原体。36至<72月龄患儿肺炎支原体检测率最高。29例患儿（26.9%）同时检测出肺炎链球菌和流感嗜血杆菌，肺炎链球菌主要在<24月龄患儿中检测出。鲍曼不动杆菌、白色念珠菌和肺炎克雷伯菌各有3例患儿检测出。31例支气管肺炎患儿中，9例检测出流感嗜血杆菌，最高检出率为29%。34例大叶性肺炎患儿中，22例检测出肺炎支原体，最高检出率为65%。22例支气管异物合并支气管肺炎患儿中，10例检测出肺炎链球菌，最高检出率为45%。