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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Tresham J J, Whitworth J A, de Lima J J, McDougall J G, Scoggins B A

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1988 May;15(5):419-25. doi: 10.1111/j.1440-1681.1988.tb01095.x.

This study was designed to test the haemodynamic and renal effects in sheep of dihydrocyclosporin D (dCyD), an immunosuppressant agent derived from the fungus Tolypocladium inflatum Gams. 2. dCyD was infused for 5 days at 12 mg/kg per day. Mean arterial pressure (MAP) was elevated after 24 h, but thereafter returned to control levels. Heart rate was significantly elevated throughout the infusion and was still high 24 h postinfusion. Cardiac output rose after 5 days, but total peripheral resistance was unchanged during the infusion. 3. Glomerular filtration rate, renal blood flow and effective renal plasma flow remained unchanged, although urine sodium excretion rose for the first 48 h. 4. Infusion of the castor oil-based vehicle for cyclosporin, Cremaphore EL, for 5 days in four sheep did not produce any sustained changes in any of the parameters measured.

本研究旨在测试二氢环孢菌素D（dCyD）对绵羊的血流动力学和肾脏的影响，dCyD是一种从真菌Inflatum Tolypocladium Gams中提取的免疫抑制剂。2. 以每天12mg/kg的剂量对dCyD进行5天的输注。24小时后平均动脉压（MAP）升高，但此后又恢复到对照水平。在整个输注过程中，心率显著升高，并且在输注后24小时仍处于较高水平。5天后心输出量增加，但在输注过程中总外周阻力未发生变化。3. 尽管在最初的48小时内尿钠排泄增加，但肾小球滤过率、肾血流量和有效肾血浆流量保持不变。4. 对四只绵羊输注环孢菌素的蓖麻油基载体聚氧乙烯蓖麻油（Cremaphore EL）5天，所测的任何参数均未产生任何持续性变化。

Tresham J J, Whitworth J A, de Lima J J, McDougall J G, Scoggins B A

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1988 May;15(5):419-25. doi: 10.1111/j.1440-1681.1988.tb01095.x.

This study was designed to test the haemodynamic and renal effects in sheep of dihydrocyclosporin D (dCyD), an immunosuppressant agent derived from the fungus Tolypocladium inflatum Gams. 2. dCyD was infused for 5 days at 12 mg/kg per day. Mean arterial pressure (MAP) was elevated after 24 h, but thereafter returned to control levels. Heart rate was significantly elevated throughout the infusion and was still high 24 h postinfusion. Cardiac output rose after 5 days, but total peripheral resistance was unchanged during the infusion. 3. Glomerular filtration rate, renal blood flow and effective renal plasma flow remained unchanged, although urine sodium excretion rose for the first 48 h. 4. Infusion of the castor oil-based vehicle for cyclosporin, Cremaphore EL, for 5 days in four sheep did not produce any sustained changes in any of the parameters measured.

本研究旨在测试二氢环孢菌素D（dCyD）对绵羊的血流动力学和肾脏的影响，dCyD是一种从真菌Inflatum Tolypocladium Gams中提取的免疫抑制剂。2. 以每天12mg/kg的剂量对dCyD进行5天的输注。24小时后平均动脉压（MAP）升高，但此后又恢复到对照水平。在整个输注过程中，心率显著升高，并且在输注后24小时仍处于较高水平。5天后心输出量增加，但在输注过程中总外周阻力未发生变化。3. 尽管在最初的48小时内尿钠排泄增加，但肾小球滤过率、肾血流量和有效肾血浆流量保持不变。4. 对四只绵羊输注环孢菌素的蓖麻油基载体聚氧乙烯蓖麻油（Cremaphore EL）5天，所测的任何参数均未产生任何持续性变化。