Mitchell S C
Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, Paddington, London, U.K.
Drug Metabol Drug Interact. 1988;6(3-4):245-52. doi: 10.1515/dmdi.1988.6.3-4.245.
The addition of an oxygen atom to the sulphur centre of a compound, with the formation of a polarized S-O moiety, alters the physical and chemical properties of the molecule and can profoundly influence its biological activity, its disposition within the body and its potential fate. Examples are given to illustrate these points.
在化合物的硫中心添加一个氧原子，形成一个极化的S-O部分，会改变分子的物理和化学性质，并能深刻影响其生物活性、在体内的分布以及潜在的命运。文中给出了实例来说明这些要点。
