作者更正：Sin1磷酸化损害mTORC2复合物的完整性并抑制下游Akt信号传导以抑制肿瘤发生。

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

作者信息

Liu Pengda, Gan Wenjian, Inuzuka Hiroyuki, Lazorchak Adam S, Gao Daming, Arojo Omotooke, Liu Dou, Wan Lixin, Zhai Bo, Yu Yonghao, Yuan Min, Kim Byeong Mo, Shaik Shavali, Menon Suchithra, Gygi Steven P, Lee Tae Ho, Asara John M, Manning Brendan D, Blenis John, Su Bing, Wei Wenyi

机构信息

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA.

Department of Immunobiology and The Vascular Biology and Therapeutics Program, Yale Medical School, New Haven, Connecticut, 06520, USA.

出版信息

Nat Cell Biol. 2019 May;21(5):662-663. doi: 10.1038/s41556-019-0280-y.

DOI:10.1038/s41556-019-0280-y

PMID:30783264

Abstract

In the version of this Article originally published, the labels for Rictor and mTOR in the whole cell lysate (WCL) blots were swapped in Fig. 3b and the mTOR blot was placed upside down. Unprocessed blots of mTOR were also missing from Supplementary Fig. 9. The corrected Figs are shown below. In addition, control blots for the mTOR antibody (Cell Signalling Technology #2972) were also missing. These are now provided below, as Fig. 9, and show that the lower band is likely non-specific.

摘要

在本文最初发表的版本中，图3b中全细胞裂解物（WCL）印迹里Rictor和mTOR的标签被互换了，并且mTOR印迹被倒置了。补充图9中也缺少mTOR的未处理印迹。下面展示了更正后的图。此外，mTOR抗体（Cell Signalling Technology #2972）的对照印迹也缺失了。现在将这些对照印迹作为图9提供在下面，显示较低条带可能是非特异性的。