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Analysis of the causes of false negative and false positive results of preoperative axillary ultrasound in patients with early breast cancer - a single-centre study.

作者信息

Nowikiewicz Tomasz, Nowak Adam, Wiśniewska Magdalena, Wiśniewski Michał, Nowikiewicz Magdalena, Zegarski Wojciech

机构信息

Chair and Department of Surgical Oncology, Ludwik Rydygier's Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.

Department of Breast Cancer and Reconstructive Surgery, Prof. Franciszek Łukaszczyk Oncology Centre, Bydgoszcz, Poland.

出版信息

Contemp Oncol (Pozn). 2018;22(4):247-251. doi: 10.5114/wo.2018.82644. Epub 2018 Dec 31.


DOI:10.5114/wo.2018.82644
PMID:30783389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6377422/
Abstract

INTRODUCTION: Properly planned and performed diagnostic tests allow the optimal treatment option to be chosen for the patient. They also allow qualification for the correct surgical procedure. AIM OF THE STUDY: In this study we evaluated the clinical value of preoperative ultrasound scan (USS) testing performed during primary disease staging in patients with early breast cancer qualified to sentinel lymph node biopsy (SLNB). MATERIAL AND METHODS: The group of breast cancer patients who underwent SLNB from March 2012 to May 2013. As well as the standard procedure of the preoperative diagnostics model, in each patient the USS of axillary lymph nodes was performed additionally. The results were compared with the data from postoperative pathological reports. We attempted to define the factors influencing the possibility of obtaining false positive and false negative USS results. RESULTS: The analysis comprised 172 patients. In 14.4% of cases with normal USS result the pathological result was different from the expected one (pN1). In 42.3% of patients with suspicious axillary lymph nodes the result of the pathological report was positive. The sensitivity of the USS testing was 89.3%, and the specificity was 34.4%, PPV - 85.6%, NPV - 42.3%. CONCLUSIONS: Ultrasonographic assessment of axillary lymph nodes in breast cancer patients qualified for SLNB is a test with high sensitivity and high predictive value of the positive test result. The possibility of a result contrary to the actual nodal status may result primarily from the technical limitations of USS testing.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/328e/6377422/b6dfa6dc29c1/WO-22-82644-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/328e/6377422/6048aa85763b/WO-22-82644-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/328e/6377422/b6dfa6dc29c1/WO-22-82644-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/328e/6377422/6048aa85763b/WO-22-82644-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/328e/6377422/b6dfa6dc29c1/WO-22-82644-g002.jpg

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Analysis of the causes of false negative and false positive results of preoperative axillary ultrasound in patients with early breast cancer - a single-centre study.

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引用本文的文献

[1]
Diagnostic value of applying preoperative breast ultrasound and clinicopathologic features to predict axillary lymph node burden in early invasive breast cancer: a study of 1247 patients.

BMC Cancer. 2024-1-22

本文引用的文献

[1]
Evaluation of changes to foot shape in females 5 years after mastectomy: a case-control study.

Breast Cancer Res Treat. 2017-6

[2]
Sagittal Plane Postural Changes in Female Patients with Breast Cancer after Different Surgical Techniques.

Breast J. 2017-1

[3]
The Problem of Mammographic Breast Density - The Position of the DEGUM Working Group on Breast Ultrasound.

Ultraschall Med. 2016-4

[4]
Diagnostic value of preoperative axillary lymph node ultrasound assessment in patients with breast cancer qualified for sentinel lymph node biopsy.

Wideochir Inne Tech Maloinwazyjne. 2015-7

[5]
Ultrasonography as a Guiding Method in Breast Micro-Calcification Vacuum-Assisted Biopsies.

Ultraschall Med. 2016-10

[6]
Axillary lymph nodes in breast cancer patients: sonographic evaluation.

Radiol Bras. 2014

[7]
Comparison of Cancer Yields and Diagnostic Performance of Screening Mammography vs. Supplemental Screening Ultrasound in 4394 Women with Average Risk for Breast Cancer.

Ultraschall Med. 2015-6

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Value of preoperative ultrasound-guided axillary lymph node biopsy for preventing completion axillary lymph node dissection in breast cancer: a systematic review and meta-analysis.

Ann Surg Oncol. 2014-1

[9]
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Pol Przegl Chir. 2013-4

[10]
Axillary staging prior to neoadjuvant chemotherapy: the roles of sentinel lymph node biopsy and axillary ultrasonography.

Cancer Control. 2012-10

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