College of Pharmacy, The University of Texas at Austin, 2409 West University Avenue, PHR 4.214, Austin, Texas, 78712, USA.
AAPS PharmSciTech. 2019 Feb 19;20(3):117. doi: 10.1208/s12249-019-1314-2.
Orally inhaled products have well-known benefits. They allow for effective local administration of many drugs for the treatment of pulmonary disease, and they allow for rapid absorption and avoidance of first-pass metabolism of several systemically acting drugs. Several challenges remain, however, such as dosing limitations, low and variable deposition of the drug in the lungs, and high drug deposition in the oropharynx region. These challenges have stimulated the development of new delivery technologies. Both formulation improvements and new device technologies have been developed through an improved understanding of the mechanisms of aerosolization and lung deposition. These new advancements in formulations have enabled improved aerosolization by controlling particle properties such as density, size, shape, and surface energy. New device technologies emerging in the marketplace focus on minimizing patient errors, expanding the range of inhaled drugs, improving delivery efficiency, increasing dose consistency and dosage levels, and simplifying device operation. Many of these new technologies have the potential to improve patient compliance. This article reviews how new delivery technologies in the form of new formulations and new devices enhance orally inhaled products.
口服吸入产品具有明显的优势。它们可有效将许多治疗肺部疾病的药物递送到肺部局部,还能使药物快速吸收并避免某些全身作用药物的首过代谢。然而,目前仍存在一些挑战,如剂量限制、肺部药物沉积率低且变化大、药物在口咽部沉积率高。这些挑战刺激了新的输送技术的发展。通过对气溶胶化和肺部沉积机制的深入了解,人们已经开发出了改进配方和新型设备技术。这些新的制剂进展通过控制颗粒的特性(如密度、大小、形状和表面能)来实现更好的气溶胶化效果。市场上涌现出的新型设备技术专注于减少患者错误、扩大吸入药物的适用范围、提高输送效率、提高剂量一致性和剂量水平以及简化设备操作。这些新技术中的许多都有可能提高患者的顺应性。本文综述了新型制剂和新型设备等新型输送技术如何增强口服吸入产品的效果。
AAPS PharmSciTech. 2019-2-19
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