Lynn B
Department of Physiology, University College, London, UK.
Skin Pharmacol. 1988;1(4):217-24. doi: 10.1159/000210778.
The main elements of neurogenic inflammation in the skin--antidromic vasodilatation, axon reflex flare and neurogenic plasma extravasation--are briefly described. New evidence is presented for a contribution from small myelinated fibres, as well as unmyelinated fibres, to antidromic vasodilatation. The mechanisms underlying flare are discussed and it is argued that weak coupling between C-fibre terminals must be important in determining the extent of spread of vasodilatation. The extent to which neurogenic factors contribute to a range of inflammatory models and to inflammatory disease states is discussed; it is argued that the importance of neurogenic mechanisms may have been underestimated.
本文简要描述了皮肤神经源性炎症的主要要素——逆向性血管舒张、轴突反射性潮红和神经源性血浆外渗。新证据表明，有髓小纤维以及无髓纤维都参与了逆向性血管舒张。本文讨论了潮红背后的机制，并认为C纤维终末之间的弱耦合对于决定血管舒张的扩散程度必定很重要。本文还讨论了神经源性因素在一系列炎症模型和炎症疾病状态中的作用程度；有人认为神经源性机制的重要性可能被低估了。
