Department of Orthopaedic Surgery, Toho University Omori Medical Center, Tokyo, Japan.
Departments of Orthopaedics and Rheumatology, Toho University Sakura Medical Center, Chiba, Japan.
Mod Rheumatol. 2020 Mar;30(2):282-286. doi: 10.1080/14397595.2019.1583783. Epub 2019 Mar 25.
To compare the inflammation of synovium before and after biological agents in the patients with rheumatoid arthritis (RA) and to investigate the association between synovial histopathology and disease activity. Synovial tissues were obtained during operations from 34 patients before and after treatment with biological agents. The synovial tissue was evaluated using hematoxylin and eosin staining. Synovial histopathology was evaluated by Rooney score. The Rooney score was also significantly decreased after treatment with biological agents in all items ( < .001). After the treatment with biological agents, Moderate disease activity group had significantly higher scores of focal aggregates of lymphocytes ( = .02), diffuse infiltrates of lymphocytes ( = .019), and the Rooney total scores ( = .002) than remission and low disease activity groups. Our results demonstrated that biological agents significantly decreased the RA synovial inflammation and synovial histopathology in sublining layer reflected disease activity.
比较类风湿关节炎（RA）患者生物制剂治疗前后的滑膜炎症，并探讨滑膜组织病理学与疾病活动度之间的关系。对 34 例接受生物制剂治疗前后的患者滑膜组织进行手术采集，采用苏木精-伊红染色评估滑膜组织，采用 Rooney 评分评估滑膜组织病理学。所有项目的 Rooney 评分在接受生物制剂治疗后均显著降低（ < .001）。在接受生物制剂治疗后，中度疾病活动组在局灶性淋巴细胞聚集（ = .02）、弥漫性淋巴细胞浸润（ = .019）和 Rooney 总评分（ = .002）方面的得分明显高于缓解和低疾病活动组。我们的结果表明，生物制剂显著降低了 RA 滑膜炎症和反映疾病活动度的固有层下滑膜组织病理学。
