尿中性粒细胞明胶酶相关脂质运载蛋白用于自发性细菌性腹膜炎的诊断。
Urinary neutrophil gelatinase-associated lipocalin for diagnosis of spontaneous bacterial peritonitis.
作者信息
Fouad Tamer R, Abdelsameea Eman, Elsabaawy Maha, Ashraf Eljaky M, Zaki El-Shenawy Soha, Omar Nabil
机构信息
1 Hepatology and Gastroenterology Department, National Liver Institute, Menofia University, Menofia Governate, Egypt.
2 Clinical Biochemistry Department, National Liver Institute, Menofia University, Menofia Governate, Egypt.
出版信息
Trop Doct. 2019 Jul;49(3):189-192. doi: 10.1177/0049475519830265. Epub 2019 Feb 20.
Cirrhotic patients with ascites are at high risk of developing spontaneous bacterial peritonitis (SBP). After exclusion of patients with acute kidney injury (AKI) or other infections, urinary neutrophil gelatinase-associated lipocalin (NGAL) levels were compared between two matched groups of Egyptian cirrhotic patients with ascites, mostly secondary to hepatitis C infection (98%). Group 1 had SBP (n = 41) and group 2 did not (n = 45). By univariate analysis, urinary-NGAL, high total bilirubin, serum creatinine, international normalised ratio and the Model of End-Stage Liver Disease (MELD) score and low platelet count were all significantly correlated with the presence of SBP, but only urinary-NGAL could independently predict development of SBP ( = 0.001). Urinary-NGAL at a cut-off value of 1225 pg/mL, showed a sensitivity of 95% and a specificity of 76%, and is therefore a most useful tool.
肝硬化腹水患者发生自发性细菌性腹膜炎（SBP）的风险很高。在排除急性肾损伤（AKI）或其他感染患者后，对两组匹配的埃及肝硬化腹水患者（大多继发于丙型肝炎感染，占98%）的尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）水平进行了比较。第1组患有SBP（n = 41），第2组未患SBP（n = 45）。单因素分析显示，尿NGAL、高总胆红素、血清肌酐、国际标准化比值、终末期肝病模型（MELD）评分以及低血小板计数均与SBP的存在显著相关，但只有尿NGAL能够独立预测SBP的发生（P = 0.001）。尿NGAL的临界值为1225 pg/mL时，敏感性为95%，特异性为76%，因此是一种非常有用的工具。
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