Al-Homood Ibrahim Abdulrazag, Omran Narges E, Alwahibi Abdulrahman S, Aldosoghy Maha, Alharthy Amal, Aljohani Ghassan S
Medical Specialties Department, Rheumatology Section, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
Department of Internal Medicine, Al Noor Specialist Hospital, Mecca, Kingdom of Saudi Arabia.
Saudi J Med Med Sci. 2017 Sep-Dec;5(3):248-253. doi: 10.4103/sjmms.sjmms_79_16. Epub 2017 Aug 21.
Neuropsychiatric disorders including depression are common clinical manifestations of systemic lupus erythematosus (SLE). Depression in patients with SLE is under-recognized, although it is a treatable clinical entity. The present study aimed to determine the prevalence of depression and identify the relationship between depression and SLE disease characteristics.
This multicenter cross-sectional study was conducted in the rheumatology clinics of four tertiary referral hospitals in Saudi Arabia between April and September 2014. Patients' demographic data and SLE disease characteristics such as disease duration, severity and drug treatments were collected. A validated Arabic Beck Depression Inventory (BDI) score was used to estimate the prevalence of depression.
A total of 68 patients with SLE (64 women, 4 men) were enrolled in the study. Forty-six (67.6%) patients were found to have BDI scores indicating depression; of them, only four patients (8.7%) were receiving antidepressant treatments. Higher prevalence of depression was associated with steroid treatment ( = 0.046).
The study results revealed high prevalence of depression among Saudi patients with SLE. Most of the study population were not adequately treated, suggesting inadequate recognition and treatment of depression in SLE.
包括抑郁症在内的神经精神障碍是系统性红斑狼疮（SLE）常见的临床表现。SLE患者的抑郁症虽为可治疗的临床病症，但目前未得到充分认识。本研究旨在确定抑郁症的患病率，并明确抑郁症与SLE疾病特征之间的关系。
本多中心横断面研究于2014年4月至9月在沙特阿拉伯4家三级转诊医院的风湿病门诊进行。收集患者的人口统计学数据以及SLE疾病特征，如病程、严重程度和药物治疗情况。采用经过验证的阿拉伯语贝克抑郁量表（BDI）评分来评估抑郁症的患病率。
本研究共纳入68例SLE患者（64例女性，4例男性）。发现46例（67.6%）患者的BDI评分表明存在抑郁；其中仅有4例患者（8.7%）正在接受抗抑郁治疗。抑郁症的较高患病率与类固醇治疗相关（P = 0.046）。
研究结果显示沙特SLE患者中抑郁症患病率较高。大多数研究对象未得到充分治疗，这表明SLE患者的抑郁症未得到充分认识和治疗。
