Macêdo E A, Appenzeller S, Costallat L T L
Department of Medicine, State University of Campinas, Campinas, Brazil
Department of Medicine, State University of Campinas, Campinas, Brazil.
Lupus. 2016 Oct;25(12):1315-27. doi: 10.1177/0961203316638934. Epub 2016 Mar 16.
Several studies have demonstrated a high prevalence of depression and anxiety in patients with systemic lupus erythematosus (SLE); however, few data address gender differences regarding these manifestations. This study aimed to investigate gender differences in the prevalence of depressive and anxiety symptoms, and their effect on the quality of life (QOL) of male and female SLE patients. This study included 54 male SLE patients, 54 female SLE patients, 54 male controls and 54 female controls. Depressive symptoms were assessed using the Beck Depression Inventory (BDI), the Center for Epidemiologic Studies Depression Scale (CES-D) and the Hospital Anxiety and Depression Scale (HADS); the anxiety symptoms were examined using HADS. We used the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) to assess QOL. Depressive symptoms were found in 22.2% of BDI respondents, 24.1% of CES-D respondents and 13% of HADS-D respondents who were male SLE patients; while in the female SLE patient group, they were found in 38.9% of BDI respondents (p = 0.063), 51.9% of CES-D respondents (p = 0.653) and 31.5% of HADS-D respondents (p = 0.003). Anxiety symptoms were found in 16.7% of the male SLE patients and 38.9% of the female SLE patients (p = 0.024). Lower scores on the SF-36 (for QOL) were found in both male and female SLE patients with depression and anxiety symptoms. In conclusion, we observed significant gender differences regarding the prevalence of depressive and anxiety symptoms in patients with SLE, with significantly higher values in the female group. The presence of these symptoms appears to have a negative effect on the QOL of patients of both genders.
多项研究表明，系统性红斑狼疮（SLE）患者中抑郁症和焦虑症的患病率很高；然而，关于这些表现的性别差异的数据很少。本研究旨在调查抑郁和焦虑症状患病率的性别差异，以及它们对男性和女性SLE患者生活质量（QOL）的影响。本研究纳入了54名男性SLE患者、54名女性SLE患者、54名男性对照者和54名女性对照者。使用贝克抑郁量表（BDI）、流行病学研究中心抑郁量表（CES-D）和医院焦虑抑郁量表（HADS）评估抑郁症状；使用HADS检查焦虑症状。我们使用医学结局研究36项简短健康调查（SF-36）来评估生活质量。在男性SLE患者中，BDI受访者中有22.2%、CES-D受访者中有24.1%、HADS-D受访者中有13%存在抑郁症状；而在女性SLE患者组中，BDI受访者中有38.9%（p = 0.063）、CES-D受访者中有51.9%（p = 0.653）、HADS-D受访者中有31.5%（p = 0.003）存在抑郁症状。焦虑症状在16.7%的男性SLE患者和38.9%的女性SLE患者中被发现（p = 0.024）。有抑郁和焦虑症状的男性和女性SLE患者在SF-36（生活质量）上的得分较低。总之，我们观察到SLE患者在抑郁和焦虑症状患病率方面存在显著的性别差异，女性组的值显著更高。这些症状的存在似乎对两性患者的生活质量都有负面影响。
