Alshalawi Abdulaziz, Alkhaibary Ali, Basalamah Ali, Alassiri Ali H, Alarifi Abdulaziz
College of Medicine, Taif University, Taif, Saudi Arabia.
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
J Surg Case Rep. 2019 Feb 8;2019(2):rjz030. doi: 10.1093/jscr/rjz030. eCollection 2019 Feb.
The simultaneous development of two or more primary central nervous system (CNS) tumors of different cell types represents 0.9% of all diagnosed CNS tumors. To the best of our knowledge, the simultaneous occurrence of glioblastoma and pituitary adenomas has been reported four times in the English literature, with only two cases harboring prolactinoma and glioblastoma. We report a case of a 42-year-old male who was diagnosed with a sporadic co-occurrence of glioblastoma and a prolactin-secreting pituitary adenoma (prolactinoma). This case report discusses the clinical presentation, radiological/histopathological features, and outcome as well as reviewing the pertinent medical literature. Glioblastoma and a prolactin-secreting adenoma may be detected within the same patient. Further studies are required to delineate the tumorigenesis of the development and co-occurrence of multiple intracranial tumors.
两种或更多种不同细胞类型的原发性中枢神经系统（CNS）肿瘤同时发生占所有确诊CNS肿瘤的0.9%。据我们所知，英文文献中仅四次报道过胶质母细胞瘤和垂体腺瘤同时出现的情况，其中仅有两例为催乳素瘤和胶质母细胞瘤。我们报告一例42岁男性患者，其被诊断为散发性胶质母细胞瘤与分泌催乳素的垂体腺瘤（催乳素瘤）同时存在。本病例报告讨论了临床表现、放射学/组织病理学特征及转归，并复习了相关医学文献。胶质母细胞瘤和分泌催乳素的腺瘤可能在同一患者体内被检测到。需要进一步研究来阐明多种颅内肿瘤发生和同时出现的肿瘤发生机制。
