Gutkin Paulina M, Hiniker Susan M, Swetter Susan M, Reddy Sunil A, Knox Susan J
Radiation Oncology, Stanford University Medical Center, Stanford, USA.
Dermatology, Stanford University Medical Center, Stanford, USA.
Cureus. 2018 Dec 12;10(12):e3723. doi: 10.7759/cureus.3723.
The combined use of immunotherapy and radiation therapy is emerging as a potentially effective treatment for patients with immunogenic tumors such as melanoma; however, evidence for long-term treatment outcomes is lacking. Herein, we summarize our previously described case study of a patient with metastatic melanoma treated with two cycles of ipilimumab, followed by stereotactic body radiotherapy to two of seven liver metastases, with two additional cycles of ipilimumab. In the longest follow-up to date, we report a successful treatment outcome at 6.5 years. Our patient remains in complete remission, with no evidence of disease or recurrence 6.5 years after treatment. He continues to manage chronic hypophysitis developed secondary to immunotherapy and has developed osteopenia from prolonged systemic glucocorticoid use. The use of radiotherapy in combination with targeted immune therapy appears to be an effective treatment strategy, with long-lasting efficacy.
免疫疗法和放射疗法的联合应用正在成为治疗黑色素瘤等免疫原性肿瘤患者的一种潜在有效方法；然而，缺乏长期治疗结果的证据。在此，我们总结了我们之前描述的一例转移性黑色素瘤患者的病例研究，该患者接受了两个周期的伊匹单抗治疗，随后对七个肝转移灶中的两个进行了立体定向体部放疗，之后又接受了两个周期的伊匹单抗治疗。在迄今为止最长的随访中，我们报告了6.5年时的成功治疗结果。我们的患者仍处于完全缓解状态，治疗6.5年后无疾病或复发迹象。他继续应对免疫疗法继发的慢性垂体炎，并因长期使用全身性糖皮质激素而出现了骨质减少。放射疗法与靶向免疫疗法联合使用似乎是一种有效的治疗策略，具有持久的疗效。
