CXCL8-CXCR1/2轴作为乳腺癌干细胞样细胞的治疗靶点
The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells.
作者信息
Ruffini Pier Adelchi
机构信息
Research and Development Department, Dompé farmaceutici S.p.A., Milan, Italy.
出版信息
Front Oncol. 2019 Feb 6;9:40. doi: 10.3389/fonc.2019.00040. eCollection 2019.
Abstract
Cancer stem-like cells (CSC) have been targeted by different strategies over the last decade. This mini review focuses on preclinical and clinical results obtained by interfering with chemokine receptors CXCR1 and CXCR2 in breast cancer. This strategy is currently being tested in a randomized, double blind phase 2 clinical trial.
摘要
在过去十年中，癌症干细胞（CSC）已成为不同治疗策略的靶点。这篇小型综述聚焦于通过干扰乳腺癌中的趋化因子受体CXCR1和CXCR2所取得的临床前和临床研究成果。目前，该策略正在一项随机、双盲的2期临床试验中进行测试。
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2
New Opportunities and Challenges to Defeat Cancer Stem Cells.战胜癌症干细胞的新机遇与挑战。
Trends Cancer. 2017 Nov;3(11):780-796. doi: 10.1016/j.trecan.2017.08.007. Epub 2017 Sep 21.
3
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Clin Cancer Res. 2017 Sep 15;23(18):5358-5365. doi: 10.1158/1078-0432.CCR-16-2748. Epub 2017 May 24.
4
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Oncotarget. 2017 May 30;8(22):35946-35961. doi: 10.18632/oncotarget.16412.
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Oncotarget. 2017 Feb 28;8(9):14428-14442. doi: 10.18632/oncotarget.14803.
6
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7
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Oncotarget. 2015 Dec 22;6(41):43375-94. doi: 10.18632/oncotarget.6234.
8
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Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5429-38. doi: 10.1073/pnas.1421438111. Epub 2014 Dec 1.
9
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10
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Sci Rep. 2014 Aug 1;4:5911. doi: 10.1038/srep05911.
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