Margiotta V, Gallo P
Stomatol Mediterr. 1988 Oct-Dec;8(4):351-62.
Bone tissue is a dynamic system in which the net balance between resorption and apposition defines the final osseous form. This process occurs in minute asynchronous foci and results from a cascade of activations, cooperations and inhibitions of specialized cells (osteoblasts and osteoclasts). The alveolar bone resorption due to periodontal disease is a complex and dynamic chain reaction in which both osteoclasts and osteoblasts have a role in the hormonal interactions occurring during the course of the resorption activity. Both microbial and host factors as prostaglandins, endotoxins and lipoteic acid seems to be able in activating bone resorption. However bone resorption can be interchanged with repair formative episodes, more or less intense, which can delay the destructive process.
骨组织是一个动态系统，其中吸收与沉积之间的净平衡决定了最终的骨形态。这个过程发生在微小的异步病灶中，是由一系列专门细胞（成骨细胞和破骨细胞）的激活、协作和抑制所导致的。牙周疾病引起的牙槽骨吸收是一个复杂的动态连锁反应，在此过程中，破骨细胞和成骨细胞在吸收活动过程中发生的激素相互作用中都发挥着作用。微生物和宿主因素如前列腺素、内毒素和脂多糖似乎都能够激活骨吸收。然而，骨吸收可以或多或少地与修复形成阶段相互交替，这可以延缓破坏过程。
