Department of Microbiology & Immunology, School of Medicine, Emory University, 1510 Clifton Road, Atlanta, GA, USA.
Curr Top Microbiol Immunol. 2019;423:119-150. doi: 10.1007/82_2019_154.
Antibodies are the key effector molecules of the humoral immune system providing long-term protective immunity against a wide range of pathogens and regulating immune responses. Traditionally, antibody-mediated protection against microbes was thought to be mainly a result of neutralizing Fab-antigen interaction; however, an increasing number of studies show the importance of proper FcR engagement for the protective capacity of antimicrobial antibodies. In this chapter, we review FcR-mediated effector functions contributing to antimicrobial protection in a direct and indirect manner. Furthermore, we highlight recent findings about the important role of Fc-FcR interactions for antimicrobial protection in vivo and provide examples demonstrating the crucial role of proper FcR engagement for antibody-mediated protection against viruses, bacteria, fungi, and parasites.
抗体是体液免疫系统的关键效应分子，为机体提供针对广泛病原体的长期保护免疫，并调节免疫反应。传统上，抗体介导的针对微生物的保护作用被认为主要是由于中和 Fab 抗体-抗原相互作用的结果；然而，越来越多的研究表明，适当的 FcR 结合对于抗菌抗体的保护能力很重要。在本章中，我们综述了 FcR 介导的效应功能，这些功能以直接和间接的方式促进了抗菌保护。此外，我们强调了最近关于 Fc-FcR 相互作用在体内对抗菌保护的重要作用的发现，并提供了一些示例，这些示例证明了适当的 FcR 结合对于抗体介导的针对病毒、细菌、真菌和寄生虫的保护作用至关重要。
