Behavioral consequences of simultaneous postnatal exposure to MK-801 and static magnetic field in male Wistar rats.

Various experimental studies reported some neurobehavioral adverse effects of static magnetic field (SMF) exposure. The reason is unclear, but one of the possibilities might be alternations in the level of the neurotransmitters and their receptors. Considering the critical role of N-Methyl D-aspartate (NMDA) receptors in the molecular regulation of cognition, motor control, and synaptic plasticity, it is important to investigate interactions between SMF exposure and administration of NMDA receptor blockers such as MK-801. Now, we administered low-dose (0.1 mg/kg) MK-801 to the male Wistar rats, from postnatal day (P) 6 to 10 and investigate whether its effects change under the influence of SMF exposure. Morris water maze, open field test, rotarod, and elevated plus maze tests were performed on P60-63 to evaluate long-term effects on learning and memory, locomotion activities, and anxiety-like behaviors. Our results showed that administration of low-dose MK-801 did not lead to significant adverse effects on their long-term anxiety-like behaviors, locomotion, learning, and memory; however, simultaneous exposure to SMF can result in these adverse effects. In conclusion, exposure to SMF can augment the neurobehavioral effects of MK-801, by enhancing the blockage of the NMDA receptors. Further studies are required to confirm these results.