Stamper Brendan D, Davis Madison, Scott-Collins Sean, Tran Julie, Ton Caryn, Simidyan Agapi, Roberts Sigrid C
School of Pharmacy, Pacific University Oregon, Hillsboro, OR, USA.
Gene Regul Syst Bio. 2019 Feb 6;13:1177625019828350. doi: 10.1177/1177625019828350. eCollection 2019.
Since the development of high-density microarray technology in the late 1990s, global host gene expression changes in response to various stimuli have been extensively studied. More than a dozen peer-reviewed publications have investigated the effect of infection in various models since 2001. This review covers the transcriptional changes in macrophage models induced by various species and summarizes the resulting impact these studies have on our understanding of the host response to leishmaniasis in vitro. Characterization of the similarities and differences between various model systems will not only further our understanding of -induced changes to macrophage gene expression but also identify potential therapeutic targets in the future.
自20世纪90年代末高密度微阵列技术发展以来，针对各种刺激的全球宿主基因表达变化已得到广泛研究。自2001年以来，已有十几篇同行评议的出版物研究了感染在各种模型中的作用。本综述涵盖了由各种物种诱导的巨噬细胞模型中的转录变化，并总结了这些研究对我们理解体外宿主对利什曼病反应的影响。表征各种模型系统之间的异同不仅将加深我们对巨噬细胞基因表达诱导变化的理解，还将在未来识别潜在的治疗靶点。
