一名重症患者的急性凝血障碍——病例报告
Acute coagulation disorder in a critically ill patient - A case report.
作者信息
Oberhuber Agnes, Treml Benedikt, Fries Dietmar, Lorenz Ingo H, Barbara Friesenecker, Andrea Griesmacher
机构信息
Department of General and Surgical Critical Care Medicine, Medical University Innsbruck, Innsbruck, Austria.
Central Institute for Medical and Chemical Laboratory Diagnosis, Medical University of Innsbruck, Innsbruck, Austria.
出版信息
J Intensive Care Soc. 2019 Feb;20(1):86-89. doi: 10.1177/1751143718761847. Epub 2018 Mar 5.
A 79-year-old critically ill woman presented with remarkable prolongation of activated partial thromboplastin time and thrombin time combined with high levels of anti-factor IIa activity 26 days after coronary artery bypass grafting. Coagulation disorder was associated with severe bleeding. Cause of coagulopathy was accidental administration of argatroban in an unknown dosage. Clearance of argatroban was significantly prolonged because of a liver function disorder related to septic multiorgan failure. Argatroban reversal was performed with prothrombin complex concentrate.
一名79岁的重症女性在冠状动脉搭桥术后26天出现活化部分凝血活酶时间和凝血酶时间显著延长，同时伴有高水平的抗凝血酶IIa活性。凝血障碍与严重出血相关。凝血病的原因是意外给予了未知剂量的阿加曲班。由于与脓毒症多器官功能衰竭相关的肝功能障碍，阿加曲班的清除时间显著延长。使用凝血酶原复合物浓缩物进行阿加曲班的逆转。
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