Astigueta Juan C, Abad-Licham Milagros A, Agreda Folker M, Leiva Benjamin A, De la Cruz Jorge L
Oncological Urology Service, Regional Neoplastic Disease Institute, Trujillo 13007, Peru.
School of Medicine, Antenor Orrego Private University, Trujillo 13007, Peru.
Ecancermedicalscience. 2018 Dec 18;12:888. doi: 10.3332/ecancer.2018.888. eCollection 2018.
Spontaneous regression of a primary testicular germ-cell tumour (GCT), over time known as 'Burned out', 'Shrinking Seminoma', 'pT0', 'Burnout' or 'Spontaneous Regression', is an uncommon, generally metastatic phenomenon, which may present elevated tumour markers and a suspicious testicular ultrasound image. The histological study of the testicle demonstrated morphological changes of complete or partial tumour regression and found fibrous scarring and other characteristic changes of this phenomenon, which in some cases include vestiges of GCT. There are few publications on testicular GCT tumour regression and those that exist present limited data on the biology of the disease and its etiopathogenesis. This entity was recently recognised in the latest edition of the World Health Organization's (WHO) Classification of Tumours. We present our clinical, imaging, laboratory, cytohistological and management experience, as well as a historical review of the literature.
原发性睾丸生殖细胞肿瘤（GCT）的自发消退，长期以来被称为“消退型”“萎缩性精原细胞瘤”“pT0”“消退”或“自发消退”，是一种罕见的、通常为转移性的现象，可能表现为肿瘤标志物升高和睾丸超声图像可疑。对睾丸的组织学研究显示了肿瘤完全或部分消退的形态学变化，并发现了这种现象的纤维瘢痕形成和其他特征性变化，在某些情况下还包括GCT的遗迹。关于睾丸GCT肿瘤消退的出版物很少，现有的那些文献提供的关于该疾病生物学及其病因发病机制的数据有限。这一实体最近在世界卫生组织（WHO）最新版的肿瘤分类中得到了认可。我们展示了我们的临床、影像学、实验室、细胞组织学和管理经验，以及对文献的历史回顾。
